2010 Fiscal Year Final Research Report
Involvement of dendritic cells in pathophysiology of the acute phase of Kawasaki disease
| Project/Area Number |
20591291
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Kurume University |
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Principal Investigator |
SUDA Kenji Kurume University, 医学部, 准教授 (10399173)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Tomoyuki 久留米大学, 医学部, 准教授 (20332687)
YASUKAWA Hideo 久留米大学, 医学部, 講師 (60289361)
IEMURA Motofumi 久留米大学, 医学部, 助教 (30399175)
MUTA Hiromi 久留米大学, 医学部, 助教 (40343694)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 川崎病 / 樹状細胞 / サイトカイン / ケモカイン |
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| Research Abstract |
The number of circulating myeloid dendritic cells (DC) significantly decreased in Kawasaki disease (KD) at presentation than in controls. In KD, the number of myeloid and plasmacytoid DC significantly correlated with disease severity represented by serum albumin and interleukin-6. This decreased number of mDC quickly normalized after immunoglobulin treatment.
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Research Products
(53 results)
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[Journal Article] Long-term prognosis of patients with Kawasaki disease complicated by giant coronary aneurysms : a single- institution experience.2011
Author(s)
Suda K, Iemura M, Nishiono H, Teramachi Y, Koteda Y, Kishim oto S, Kudo Y, Itoh S, Ishii H, Ueno T, Tashiro T, Nobuyoshi M, Kato H, Matsuishi T.
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Journal Title
Circulation 123(17)
Pages: 1836-42
Peer Reviewed
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[Presentation] Involvement of myeloid dendritic cell in the pathogenesis of acute phase of Kawasaki disease.2010
Author(s)
Suda K, Kishimoto S , Takahashi T, Okamura H, Yasukawa H, Nishino H, Teramachi Y, Itoh S , Yokoyama T, Iemura M, Imaizumi T, Matsuishi T.
Organizer
The 74^<th> annual scientific meeting of the Japanese Circulation Society.
Place of Presentation
Kyoto, Japan
Year and Date
20100305-20100307
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[Presentation] 川崎病急性期のBNP2008
Author(s)
岸本慎太郎,須田憲治,籠手田雄介,工藤嘉公,伊藤晋一,石井治佳,西野裕,寺町陽三,家村素史,吉本裕良,松石豊次郎
Organizer
第44回日本小児循環器学会
Place of Presentation
郡山
Year and Date
20080702-20080704
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[Presentation] Change of antibody titers against measles in patients with Kawasaki Disease treated with intravenous gamma globulin.2008
Author(s)
Ishii H, Suda K, Kishimoto S, Koteda Y, Iemura M, Kudo Y, Itoh S, Nishino H, Teramachi Y, Matsuishi T.
Organizer
9th International Kawasaki Disease Symposium
Place of Presentation
Taipei, Taiwan
Year and Date
20080410-20080412
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[Presentation] Transient subclinical ventricular dysfunction after intravenous gamma globulin infusion in patients with Kawasaki Disease.2008
Author(s)
Suda K, Kishimoto S, Koteda Y, Kudo Y, Itoh S, Ishii H, Nishino H, Teramachi Y, Iemura M, Matsuishi T.
Organizer
9th International Kawasaki Disease Symposium
Place of Presentation
Taipei, Taiwan
Year and Date
20080410-20080412
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[Presentation] Impaired micro-vascular hyperaemic response by laser doppler monitoring in patients with coronary artery aneurysms due to Kawasaki Disease.2008
Author(s)
Iemura M, Sugimura T, Kishimoto S, Koteda Y, Ishii H, Kudo Y, Itoh S, Nishino H, Teramachi Y, Suda K, Matsuishi T.
Organizer
9th International Kawasaki Disease Symposium
Place of Presentation
Taipei, Taiwan
Year and Date
20080410-20080412
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