2010 Fiscal Year Final Research Report
Studies on the neutrophil-mediated transport of Shiga toxins
| Project/Area Number |
20591293
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | National Research Institute for Child Health and Development |
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Principal Investigator |
TSUNAWAKI Shohko National Research Institute for Child Health and Development, 研究所・母児感染研究部, 室長 (00211384)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 好中球 / 志賀毒素 / スフィンゴ糖脂質 / 溶血性尿毒症 / ラクトシルセラミド |
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| Research Abstract |
Enterohemorrhagic Escherichia coli (EHEC), a major pathogen of pediatric hemorrhagic colitis, cause hemolytic uremic syndrome (HUS) and encephalopathy. Shiga toxins (Stx1 and Stx2) produced by EHEC damage target cells which highly express Gb3, but the transport mechanism of Stxs from the intestinal tract to the target cells is unclear. In this study, we demonstrate that Stxs bind to LacCer in neutrophils and accumulate in the nucleus bypassing lysosomes and Golgi bodies. In view of neutrophil accumulation in glomeruli of patients with HUS, they should transport Stxs to target cells from the intestinal tract.
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[Journal Article] Monocarboxylate transporter-1 is required for cell death in mouse chondrocytic ATDC5 cells exposed to interleukin-1b via late-phase activation of nuclear factor кB and expression of phagocyte-type NADPH-oxidase.2011
Author(s)
Yoshimura K, Miyamoto Y, Yasuhara R, Maruyama T, Akiyama T, Yamada A, Takami M, Suzawa T, Tsunawaki S, Tachikawa T, Baba K, Kamijo R.
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Journal Title
J Biol Chem. 286
Pages: 14744-14752
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