2010 Fiscal Year Final Research Report
Molecular mechanism of gender dependent difference in the neural tube defect manifestation.
| Project/Area Number |
20591297
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Tottori University |
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Principal Investigator |
NARUSE Ichiro Tottori University, 医学部, 教授 (20113326)
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| Co-Investigator(Kenkyū-buntansha) |
UETA Etsuko 鳥取大学, 医学部, 講師 (40335526)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 先天異常 |
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| Research Abstract |
Prevalence of neural tube defects (NTDs) is larger in female in human. Pdn/Pdn mouse, whose responsible gene is Gli3, has a 16% risk of NTDs, and confines in female. When Ochratoxin A (OTA) was exposed to Pdn/Pdn mouse embryo, only male Pdn/Pdn manifested increased incidence of NTDs. After exposure to OTA on day 7.5 of gestation, Daam, Hoxbl, Tbx, Hmx3, Dlxl, Tlxh gene expressions were severely up-regulated in the +/+ and Pdn/Pdn embryos on day 9 of gestation. Ectopic expressions of Fgf8 and Emx2 were observed in the OTA-treated Pdn/Pdn embryos. From these investigations, it was speculated that NTDs manifestation is induced by the altered multiple gene expressions.
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