Cerebral oxygenation and hemodynamics in premature infant using near-infrared time-resolved spectroscopy

2010 Fiscal Year Final Research Report

• Project/Area Number: 20591299
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Embryonic/Neonatal medicine
• Research Institution: Kagawa University
• Principal Investigator: ISOBE Kenichi 香川大学, 医学部, 准教授 (00159815)
• Co-Investigator(Kenkyū-buntansha): KUSAKA Takashi 香川大学, 医学部附属病院, 講師 (50274288) ; KAWADA Kou 国立病院機構京都医療センター, 小児科, 医長 (40284369) ; OKUBO Kensuke おおくぼ小児科, 院長 (80335851) ; KUBOI Tohru 東京都立小児総合医療センター, 総合周産期母子医療センター新生児科, 医員 (00437683) ; NAKAMURA Shinji 香川大学, 医学部附属病院, 病院助教 (30437686) ; KOYANO Kousuke 香川大学, 医学部附属病院, 病院助教 (20437685) ; HISHIDA Tomoko 香川大学, 教育学部, 教授 (00243759)
• Project Period (FY): 2008 – 2010
• Keywords: 貧血 / 脳内酸素化状態 / 脳血液量 / 近赤外線分光法 / 時間分解分光装置 / 新生児未熟児 / 新生仔豚

Research Abstract

Anemia of prematurity is a common disease, particularly in very low birth weight infants, and transfusion is an important treatment. However, there is no clear evidence for the currently widely used transfusion criteria using the blood hemoglobin level (Hb) and hematocrit value (Ht). Thus, preparation of new transfusion criteria using an index other than the Hb and Ht has been attempted. We measured the cerebral Hb concentration, Hb oxygen saturation (ScO_2) and cerebral blood volume (CBV) in anemic animal model and infants with anemia of prematurity using time-resolved near-infrared spectroscopy (TRS). In animal study, we demonstrated that TRS method could be used to monitor the cerebral oxygenation and hemodynamics in the anemic neonates at the bedside. Thus, fifteen measurements were performed in 10 premature infants. CBV significantly decreased and ScO_2 significantly increased after transfusion. Measurement of CBV and ScO_2 is useful to investigate the necessity of transfusion.

Research Products

• [Journal Article] Extrauterine environment influences spontaneous low-frequency oscillations in the preterm brain (2012)
  • Author(s): Kato I, Kusaka T, Nishida T, Koyano K, Nakamura S, Nakamura M, Konishi Y, Kunikata J, Jinnai W, Yasuda S, Okada H, Itoh S, Isobe K
  • Journal Title: Brain Dev Volume: (in press)
  • Peer Reviewed
• [Journal Article] Hemodynamic changes in the breast and frontal cortex of mother during breastfeeding (2011)
  • Author(s): Tanimoto K, Kusaka T, Nishida T, Ogawa K, Kato I, Ijichi S, Mikami J, Sobue I, Isobe K, Itoh S
  • Journal Title: Pediatr Res Volume: 70 Pages: 400-405
  • Peer Reviewed
• [Journal Article] Functional lateralization of sensorimotor cortex in infants measured using multichannel near-infrared spectroscopy (2011)
  • Author(s): Kusaka T, Isobe K, Miki T, Ueno M, Koyano K, Nakamura S, Nishida T, Itoh S
  • Journal Title: Pediatr Res Volume: 69 Pages: 430-435
  • Peer Reviewed
• [Presentation] 未熟児貧血における輸血療法時の脳血液量、脳内ヘモグロビン酸素飽和度の変化について (2011)
  • Author(s): 小谷野耕佑、磯部健一他
  • Organizer: 第56回日本未熟児新生児学会
  • Place of Presentation: 東京
  • Year and Date: 2011-11-15
• [Presentation] Cerebral blood volume in anemic piglets using near-infrared time-resolved spectroscopy (2011)
  • Author(s): Kosuke Koyano, Kenichi Isobe et al.
  • Organizer: BRAIN' 11 & BRAINPET' 11
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2011-05-27
• [Presentation] The impact of blood transfusion on cerebral hemodynamics and oxygenation in anemic premature infants (2011)
  • Author(s): Kosuke Koyano, Kenichi Isobe et al.
  • Organizer: BRAIN' 11 & BRAINPET' 11
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2011-05-27
• [Presentation] Changes in cerebral blood volume of piglets with acute anemia induced by partial blood exchange transfusion (2010)
  • Author(s): Kosuke Koyano, Kenichi Isobe et al.
  • Organizer: The 6th Congress of Asian Society for Pediatric Research
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2010-04-16
• [Presentation] Effects of hemodilution on cerebral optical properties and hemodynamics in newborn piglets using near-infrared time-resolved spectroscopy (2008)
  • Author(s): Kenichi Isobe, et al.
  • Organizer: ISOTT2008
  • Place of Presentation: Sapporo, Japan
  • Year and Date: 2008-08-06