2010 Fiscal Year Final Research Report
Research of the role of tenascin C in coronary development
| Project/Area Number |
20591310
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
TOMITA Sachiko Tokyo Women's Medical University, 医学部, 助教 (40231451)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIDA Kyoko 三重大学, 医学研究科, 准教授 (00242967)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 冠動脈 / 形態形成 / テネイシンC / 発生 / 血管形成 |
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| Research Abstract |
Cells destined to form the coronary vasculature which supply oxygen and nutrients to the heart are thought to originate in the proepicardium. We examined an extracellular glycoprotein tenascin C in formation of the coronary stem and epithelial mesenchymal transformation of proepicardium-derived cells. Expression of tenascin C was seen in developing coronary stems and coronary smooth muscle cells. It is suggested that tenascin C facilitates the differentiation of proepicardium-derived cells into myofibroblast/smooth muscle cells, however, not induce the invasion/migration of the cells in vitro system.
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Research Products
(54 results)
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[Journal Article] Tenascin C induces epithelial-mesenchymal transition-like change accompanied by SRC activation and focal adhesion kinase phosphorylation in human breast cancer cells2011
Author(s)
Nagaharu K, Zhang X, Yoshida T, Katoh, D, Hanamura, N, Kozuka Y, Ogawa T, Shiraishi T, Imanaka-Yoshida K
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Journal Title
Am J Pathol 178
Pages: 754-63
Peer Reviewed
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[Journal Article] Endothelin receptor Type A expression defines a distinct cardiac subdomain within the heart field and later implicated in chamber myocardium formation2010
Author(s)
Asai R, Kurihara Y, Fujisawa K, Sato T, Kawamura Y, Kokubo H, Tonami K, Nishiyama K, Uchijima Y, Miyagawa-Tomita S, Kurihara H
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Journal Title
Development 137
Pages: 3823-3833
Peer Reviewed
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[Journal Article] Tenascin-C may aggravate left ventricular remodeling and function after myocardial infarction in mice2010
Author(s)
Nishioka T, Onishi K, Shimojo N, Nagano Y, Matsusaka H, Ikeuchi M, Ide T, Tsutsui H, Hiroe M, Yoshida T, Imanaka-Yoshida K
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Journal Title
Am J Physiol Heart Circ Physiol 298
Pages: H1072-1078
Peer Reviewed
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[Journal Article]2009
Author(s)
Shirai M, Imanaka-Yoshida K, Schneider MD, Schwartz RJ, Morisaki T
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Journal Title
Proc Natl Acad Sci USA 106
Pages: 18604-18609
Peer Reviewed
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[Presentation] テネイシンCによる心臓血管新生の制御2009
Author(s)
今中-吉田恭子,原万里,浪方美幸,レオンバルディビィアサライサベル,堰本晃代,吉田利通,宮川-富田幸子
Organizer
第13回Molecular Cardiovascular Conference
Place of Presentation
小樽
Year and Date
20090904-20090906
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[Presentation] Endothelin type-A receptor expression defines a distinct subdomain within the crescent-forming heart field contributing to chamber myocardium2009
Author(s)
Asai R, Kurihara Y, Sato T, Kawamura Y, Kokubo H, Tonami K, Uchijima Y, Saga Y, Miyagawa-Tomita S, Kurihara H
Organizer
Weinstein Cardiovascular Developmental Conference
Place of Presentation
California, USA
Year and Date
20090507-20090509
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[Presentation] Fgf autocrine loop initiated in second heart field mesoderm regulates morphogenesis at the arterial pole of the heart2008
Author(s)
Park EJ, Watanabe Y, Smyth G, Miyagawa-Tomita S, Meyers EN, Klingensmith J, Camenisch T, Buckingham M, Moon AM
Organizer
Weinstein Cardiovascular Development Conference, 9
Place of Presentation
Houston, Texas, USA
Year and Date
20080515-20080517
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