2010 Fiscal Year Final Research Report

Analyses of suppressive effect of Raf kinase inhibitor protein on cutaneous squamous cell carcinoma progression, and consideration for therapeutic use.

Research Project

Project/Area Number	20591313
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Dermatology
Research Institution	Hirosaki University
Principal Investigator	ROKUNOHE Daiki Hirosaki University, 医学部・附属病院, 助手 (50436036)
Co-Investigator(Kenkyū-buntansha)	NAKANO Hajime 弘前大学, 大学院・医学研究科, 准教授 (90281922) MATSUZAKI Yasushi 弘前大学, 医学部附属病院, 講師 (50322946)
Project Period (FY)	2008 – 2010
Keywords	皮膚腫瘍 / シグナル伝達 / 細胞増殖 / 分化 / 転移
Research Abstract	In well-and moderately-differentiated SCCs, RKIP was broadly and strongly stained in the tumor nests, and RKIP staining was stronger in the keratinizing tumor cells. On the other hand, RKIP staining was only weak or negative in poorly-differentiated SCCs. These results suggest that RKIP is associated with differentiation of cutaneous SCC and assessing RKIP expression may yield important information to the prognosis of the cutaneous SCC patients.