2010 Fiscal Year Final Research Report
Regulation mechanism in keratinocyte growth and differentiation by p53 homologue p51/p63 and Maf
| Project/Area Number |
20591314
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Tohoku University |
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Principal Investigator |
OKUYAMA Ryuhei Tohoku University, 医学部, 教授 (80292332)
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| Co-Investigator(Renkei-kenkyūsha) |
IKAWA Shuntaro 東北大学, 加齢医学研究所, 准教授 (50241576)
OGAWA EISAKU 信州大学, 医学部, 助授 (20451586)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 表皮細胞 / p51 / p63 / シグナル伝達 / デスモプラキン / 乾癬 |
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| Research Abstract |
p51/p63, a homologue of p53 tumor suppressor, is well known to play a role in oncogenesis. Simultaneously, p51/p63 promotes development of cellular characters specific for squamous cells, such as keratinocytes. Contrast to p51/p63, TGFβ suppresses these cellular characters as squamous cells, which leads to induction of cellular functions specific for mesenchymal cells. We focused on desmoplakin, calcium-dependent homophilic adhesion molecule, because the desmoplakin is a unique molecule in squamous cells. We found that desmoplakin expression is increased by p51/p63 whereas it is decreased by TGFβ.
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[Journal Article] Epidermal FABP (FABP5) regulates keratinocyte differentiation via 13(S)-HODE-mediated activation of the NF-kB signaling pathway.2011
Author(s)
Ogawa E, Owada Y, Ikawa S, Adachi Y, Egawa T, Nemoto K, Suzuki K, Hishinuma T, Kawashima H, Kondo H, Muto M, Aiba S, Okuyama R.
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Journal Title
J Invest Dermatol 131
Pages: 604-612
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[Journal Article] Mutation analysis of the SHOC2 gene in Noonan-like syndrome and in hematologic malignancies.2010
Author(s)
Komatsuzaki S, Aoki Y, Niihori T, Okamoto N, Hennekam RCM, Hopman S, Ohashi H, Mizuno S, Watanabe Y, Kamasaki H, Kondo I, Moriyama N, Kurosawa K, Kawame H, Okuyama R, Imaizumi M, Rikiishi T, Tsuchiya S, Kure S, Matsubara Y.
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Journal Title
J Hum Genet 55
Pages: 801-809
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