2010 Fiscal Year Final Research Report
The elucidation of the stimulus responses which carry out selection of the centromere autoantigens from macromolecule complexes
| Project/Area Number |
20591320
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Nagoya University |
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Principal Investigator |
MURO Yoshinao 名古屋大学, 大学院・医学系研究科, 准教授 (80270990)
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| Co-Investigator(Kenkyū-buntansha) |
SUGIURA Kazumitsu 名古屋大学, 医学系研究科, 准教授 (70335032)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 皮膚病理学 / 強皮症 / 抗セントロメア抗体 |
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| Research Abstract |
This study aimed to clarify the stimulus responses which carry out selection of centromere autoantigens from maculomolecular complexes including more than forty proteins. We examined immunoreactivities of nine different kinds of centromere proteins, which are different from three major centromere autoantigens, against sera from many patients and confirmed that a few of them reacted with a few patients'sera. At present, we have not identified any factors which might differentiate major centromere autoantigens from minor autoantigens that rarely react to autoantibodies.
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Research Products
(24 results)
