2010 Fiscal Year Final Research Report
How do mutations in the XPD result in different skin cancer susceptibilities in patients with xeroderma pigmentosum or trichothiodystrophy?
| Project/Area Number |
20591324
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Nara Medical University |
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Principal Investigator |
MORI Toshio Nara Medical University, 医学部, 研究教授 (10115280)
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| Co-Investigator(Kenkyū-buntansha) |
IWAMOTO Takaaki 奈良県立医科大学, 医学部, 博士研究員 (20448773)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 皮膚発がん / 色素性乾皮症 / 硫黄欠乏性毛髪発育異常症 / 紫外線 / XPD / TFIIH / ヌクレオチド除去修復 |
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| Research Abstract |
We studied how mutations in the XPD gene result in different skin cancer susceptibilities in patients with xeroderma pigmentosum (XP) or trichothiodystrophy (TTD). XP-D and TTD cells were both deficient in the repair of UV-induced DNA damage because of helicase activity defects of TFIIH. Since TFIIH also acts as a coactivator, TTD-specific decrease in TFIIH content possibly results in transcriptional defects, which might be implication for the lack of increased incidence of skin cancers in TTD patients.
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