2010 Fiscal Year Final Research Report
Development of new objective methods to assess disease activity in pemphigus using monoclonal single-chain- variable-fragment antibodies
| Project/Area Number |
20591328
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Keio University |
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Principal Investigator |
ISHII Ken Keio University, 医学部, 准教授 (50296670)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 皮膚科学 / 皮膚診断学 / 自己免疫性疾患 |
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| Research Abstract |
In order to develop new objective methods to assess the disease activity in pemphigus, we performed the detailed characterization of repertories of monoclonal anti-desmoglein (Dsg) 1 autoantibodies isolated from a pemphigus foliaceus patient by phage display. Major epitopes on desmoglein bound by autoantibodies in many pemphigus patients were uncovered. The reactivity against the epitopes by pemphigus sera correlates with the disease activity. These findings will facilitate the development of new objective methods to assess the disease activity in pemphigus patients.
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