2010 Fiscal Year Final Research Report
Gene therapy for refractory skin ulcer by using Histone deacetylase inhibitor
| Project/Area Number |
20591333
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Hokkaido University |
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Principal Investigator |
YASUKAWA Kana Hokkaido University, 大学院・医学研究科, 非常勤講師 (10419202)
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| Co-Investigator(Kenkyū-buntansha) |
SHIBAKI Akihiko 北海道大学, 大学院・医学研究科, 非常勤講師 (40291231)
ABE Yukiko 北海道大学, 大学院・医学研究科, 非常勤講師 (40374433)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 皮膚炎症 / 再生医療 / 免疫 / 遺伝子治療 |
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| Research Abstract |
In this study, we demonstrated that HDAC inhibitors increased transient transgene expression. This effect was observed by not only local injection but also external use. However, an ulcer reduction effect was not observed in the study using the growth factor gene. For this result, it was thought that the examination of the gene introduction number of times and the combination of growth factors were necessary.
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