2010 Fiscal Year Final Research Report
Establishment of remodeling technologies for protein misfolding in keratin disorders using an inducible transgenic mouse model
| Project/Area Number |
20591334
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Akita University |
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Principal Investigator |
MANABE Motomu Akita University, 大学院・医学系研究科, 教授 (30138309)
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| Co-Investigator(Renkei-kenkyūsha) |
河村 七美 秋田大学, 医学部, 助教 (70323152)
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| Project Period (FY) |
2008 – 2010
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| Keywords | ケラチン / 分子シャペロン / 蛋白フォールディング / 細胞死 |
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| Research Abstract |
In this grant program, we attempted to elucidate the molecular mechanisms of protein misfolding in keratin disorders. The transgenic mouse studies showed that mutated keratins cause neither collapse of keratins or apoptosis in cultured keratinocytes. These findings may be because of the DNA break of transgene in a certain point.
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