Regulation of Langerhans cell function by fibroblasts

2010 Fiscal Year Final Research Report

• Project/Area Number: 20591336
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Dermatology
• Research Institution: The University of Tokyo
• Principal Investigator: TADA Yayoi The University of Tokyo, 医学部附属病院, 講師 (00334409)
• Project Period (FY): 2008 – 2010
• Keywords: 樹状細胞 / 線維芽細胞

Research Abstract

Molecules which are released from dead cells and activate immune systems are called danger signals. We found that one of such danger signals, monosodium urate crystal, induces Langerhans cell migration to the lymph node and augment contact hypersensitivity.

Research Products

• [Journal Article] Identification of a novel marker for dendritic cell maturation, mouse transmembrane protein 123. (2010)
  • Author(s): Takekoshi T, Tada Y, Watanabe T, Sugaya M, Hoashi T, Komine M, Kawashima T, Shimizu T, Hau CS, Asahina A, Yokomizo T, Sato S, Tamaki K
  • Journal Title: J Biol Chem. 285 Pages: 31876-84
• [Journal Article] Possible roles of IL-27 in the pathogenesis of psoriasis. (2010)
  • Author(s): Shibata S, Tada Y, Kanda N, Nashiro K, Kamata M, Karakawa M, Miyagaki T, Kai H, Saeki H, Shirakata Y, Watanabe S, Tamaki K, Sato S
  • Journal Title: J Invest Dermatol. 130 Pages: 1034-9
• [Journal Article] Vaccination with TAT-antigen fusion protein induces protective, CD8(+) T cell-mediated immunity against Leishmania major. (2010)
  • Author(s): Kronenberg K, Brosch S, Butsch F, Tada Y, Shibagaki N, Udey MC, von Stebut E
  • Journal Title: J Invest Dermatol. 130 Pages: 2602-10
• [Journal Article] Atypical cutaneous sarcoidosis with diffuse, indurated erythema. (2009)
  • Author(s): Tada Y, Kanda N, Ohnishi T, Watanabe S
  • Journal Title: Eur J Dermatol. 19 Pages: 639
• [Journal Article] Novel effects of diosgenin on skin aging. (2009)
  • Author(s): Tada Y, Kanda N, Haratake A, Tobiishi M, Uchiwa H, Watanabe S
  • Journal Title: Steroids 74 Pages: 504-511
• [Journal Article] Prolactin enhances basal and IL-17-induced CCL20 production by human keratinocytes. (2009)
  • Author(s): Kanda N, Shibata S, Tada Y, Nashiro K, Tamaki K, Watanabe S
  • Journal Title: Eur J Immunol. 39 Pages: 996-1006
• [Remarks] ホームページ等