2010 Fiscal Year Final Research Report
Identification of label retaining cells in the eccrine glands.
| Project/Area Number |
20591343
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
NAKAMURA Motonobu University of Occupational and Environmental Health, Japan, 医学部, 准教授 (30303837)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 幹細胞 / 汗腺 / 再生治療 / 上皮間葉転換 |
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| Research Abstract |
To address the localization of stem cells in the mouse eccrine glands, we tried to detect label retaining cells, which are very slow cell cycling cells. Label retaining cells reside in the secretory gland and the intraglandular duct of mouse eccrine glands. To further investigate the localization of stem cells in the human eccrine glands, we transplanted human skin onto the back skin of BALB/c nude mice. We found that label retaining cells resided in the secretory gland and the intraglandular duct. These results may lead to a new regenerative therapeutic approach for severe burn or hereditary bullous diseases.
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