2010 Fiscal Year Final Research Report
Analysis for the role of physiological IgE
| Project/Area Number |
20591352
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Kyorin University |
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Principal Investigator |
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| Project Period (FY) |
2008 – 2010
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| Keywords | IgE / TLR2 / 自然免疫 |
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| Research Abstract |
The objective of this study was to investigate whether mast cell activated through the TLR on IgE-independent immediate-type hypersensitivity(ITH) response, and whether the physiological level of IgE suppressed this response. We clearly demonstrated that IgE acts not only as a deterioration effect but also as an inhibitory effect on the ITH : IgE is an important factor of regulating the activation of mast cells. In addition, we also showed that scratching would act to convert ITH responses which might otherwise be IgE-independent to IgE-dependent.
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