2010 Fiscal Year Final Research Report
Control mechanism of melanogenesis by pigmentation-related genes and ultraviolet radiation
Project/Area Number |
20591357
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Dermatology
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Research Institution | Fujita Health University |
Principal Investigator |
ITO Shosuke Fujita Health University, 藤田保健衛生大学, 名誉教授 (70121431)
|
Co-Investigator(Kenkyū-buntansha) |
WAKAMATSU Kazumasa 藤田保健衛生大学, 医療科学部, 教授 (80131259)
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Co-Investigator(Renkei-kenkyūsha) |
HIROBE Tomohisa 放射線医学総合研究所, 生体影響機構研究, グループ・チームリーダー (10111238)
|
Project Period (FY) |
2008 – 2010
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Keywords | メラニン / 遺伝子 / 紫外線 |
Research Abstract |
Our present results suggest that melanoblast/melanocyte proliferation and melanocyte differentiation are regulated in a time-and development-dependent manner by many coat color genes, especially Agouti (A), brown (Tyrp1^b/b), albino (Tyr^c/c), dilute (Myo5a^d/d), recessive yellow (Mc1r^e/e), pink-eyed dilution (Oca2^p/p), slaty (Dct^slt/slt) and ruby-eye 2^d(ru2^d/Hps5^ru2-d) otherwise known for their ability to regulate melanosome formation and maturation, pigment switching, melanosome distribution and transfer.
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[Journal Article] Abdel-Malek ZA Melanocortin 1 receptor genotype : an important determinant of the damage response of melanocytes to ultraviolet radiation2010
Author(s)
Kadekaro AL, Leachman S, Kavanagh RJ, Swope V, Cassidy P, Supp D, Sartor M, Schwemberger S, Babcock G, Wakamatsu K, Ito S, Koshoffer A, Boissy RE, Manga P, Sturm R
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Journal Title
FASEB J 24
Pages: 380-390
Peer Reviewed
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[Journal Article] Predicting phenotype from genotype : normal pigmentation2010
Author(s)
Valenzuela RK, Henderson MS, Walch MH, Garrison NA, Kelch JT, Cohen-Barak O, Erickson DT, Meaney FJ, Walsh JB, Cheng KC, Ito S, Wakamatsu K, Frudakis T, Thomas M, Brilliant MH
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Journal Title
J Forensic Sci 55
Pages: 315-322
Peer Reviewed
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[Journal Article] Short- and long-term effects of UV on the pigmentation of human skin2009
Author(s)
Coelho SG, Choi W, Brenner M, Miyamura Y, Yamaguchi Y, Wolber R, Smuda C, Kolbe L, Ito S, Wakamatsu K, Zmudzka B, Beer JZ, Miller SA, Hearing VJ
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Journal Title
J Invest Dermatol Symp Proc 14
Pages: 31-35
Peer Reviewed
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[Journal Article] Agouti protein, mahogunin, and attractin in pheomelanogenesis and melanoblast-like alteration of melanocytes : a cAMP-independent pathway2009
Author(s)
Hida T, Wakamatsu K, Sviderskaya EV, Donkin AJ, Montoliu L, Lamoreux ML, Yu B, Millhauser GL, Ito S, Barsh GS, Jimbow K, Bennett DC
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Journal Title
Pigment Cell Melanoma Res 22
Pages: 623-634
Peer Reviewed
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