2010 Fiscal Year Final Research Report
Neural mechanisms underlying stress vulnerability - involvement of neurogenesis in mood disorder
| Project/Area Number |
20591360
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Hokkaido University |
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Principal Investigator |
NAKAGAWA Shin Hokkaido University, 病院, 講師 (60360905)
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| Co-Investigator(Kenkyū-buntansha) |
INOUE Takshi 北海道大学, 病院, 講師 (70250438)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 精神薬理学 |
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| Research Abstract |
In this study we took particular note of neurogenesis in the adult hippocampus as molecular basis of stress vulnerability in the brain. In vitro studies using adult rat dentate gyrus-derived precursor cells (ADP) were done to see the direct effects of antidepressants, mood stabilizers and monoamines on them. Among them, mood stabilizers, noradrenaline, and dopamine had some effects in the aspect the proliferation, apoptosis, and differentiation. In addition we found out the involvement of CaMKIV in the action of antidepressants through neurogenesis. All these findings will contribute to make novel antidepressants.
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