2010 Fiscal Year Final Research Report

Clinical potential of minocycline for schizophrenia

Research Project

Project/Area Number	20591366
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Psychiatric science
Research Institution	Shimane University
Principal Investigator	MIYAOKA Tsuyoshi Shimane University, 医学部, 准教授 (50284047)
Project Period (FY)	2008 – 2010
Keywords	統合失調症 / ミノサイクリン / 抗精神病薬作用 / 統合失調症モデルラット
Research Abstract	Clinical potential of minocycline for schizophrenia Minocycline, an antibiotic of the tetracycline family, has been shown to display neurorestorative or neuroprotective properties in various models of neurodegenerative diseases. Despite controversies about its efficacy, the relative safety and tolerability of minocycline have led to various clinical trials. In our study, we administered minocycline as an open label adjunct to anitipsychotic medication to patients with schizophrenia. And also I assessed the effects of antipsychotics and minocycline on schizophrenia animal model. The results of these trial suggested that minocycline might be a safe and effective adjunct to antipsychotic medications, and that augmentation with minocycline may prove to be a viable strategy for "boosting" antipsychotic efficacy and for treating schizophrenia.