2010 Fiscal Year Final Research Report
Role of alpha1 adrenoceptor activation in the hypothalamic paraventricular nucleus on the adrenomedullary outflow in rats
| Project/Area Number |
20591370
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Kochi University |
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Principal Investigator |
OKADA Shoshiro Kochi University, 教育研究部・医療学系, 准教授 (40203989)
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| Project Period (FY) |
2008 – 2010
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| Keywords | NMDA / ノルアドレナリン神経系 / アドレノセプター / トロンボキサン / 血中カテコールアミン |
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| Research Abstract |
N-methyl-D-aspartate (NMDA) has been implicated in the regulation of several autonomic responses in the brain. The present study determined whether activation of α_1-adrenoceptors is involved in the centrally administered NMDA-induced adrenomedullary catecholamine outflow, using urethane-anesthetized rats. Perfusion of the hypothalamic paraventricular nucleus with NMDA (0.3 and 1.0mM) dose-dependently elevated both noradrenaline levels in the hypothalamic paraventricular nucleus and plasma catecholamine levels. These responses were abolished by co-administration of dizocilpine malate (MK-801, 0.1mM), a selective non-competitive antagonist of the NMDA receptor and by co-administration of (+)-S-145 (2.5mM), a selective competitive antagonist of the thromboxane A2 receptor. These results suggest that activation of central α_1-adrenoceptors is involved in the centrally administered NMDA-induced activation of adrenomedullary catecholamine outflow in rats. Furthermore, signaling cascades downstream of the α_1-adrenoceptor in the hypothalamic paraventricular nucleus may play an important role in the process.
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