2010 Fiscal Year Final Research Report
Role of obestatin in anxiety disorders
| Project/Area Number |
20591371
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Oita University |
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Principal Investigator |
AKIYOSHI Jotaro Oita University, 医学部, 准教授 (00159344)
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| Co-Investigator(Kenkyū-buntansha) |
HANADA Hiroaki 大分大学, 医学部, 助教 (80444884)
TANAKA Yoshihiro 大分大学, 医学部, 医員 (60516102)
ISHITOBI Yoshinobu 大分大学, 医学部, 医員 (40516118)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 不安障害 |
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| Research Abstract |
Stomach secretes ghrelin, and brain also doses it. Ghrelin have reported to be associated with depression, anxiety and eating behavior. GPR39 is a receptor for ghrelin. We examined the relationship between obestatin, depression, anxiety and eating behavior. We GPR39-1b antisense oligonucleotides were infused at a constant rate into the cerebral lateral ventricles of rats and their effect on anxiety and food intake was monitored. GPR39-1b antisense oligonucleotides produced anxiolytic-like effects in the elevated-plus maze test, and in the black and white test. GPR39-1b antisense oligonucleotides decreased food intake. These results indicate that inhibition of GPR39-1b induces a decrease in anxiety-related behaviors and disturbs appetite.
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[Journal Article] Serum hepatocyte growth factor levels and the effects of antidepressants in panic disorder.2010
Author(s)
Masayuki Kanehisa, Yoshinobu Ishitobi, Tomoko Ando, Shizuko Okamoto, Yoshihiro Maruyama, Kentaro Kohno, Taiga Ninomiya, Haruka Higuma, Yoshihiro Tanaka, Jusen Tsuru, Hiroaki Hanada, Kensuke Kodama, Jotaro Akiyoshi
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Journal Title
Neuropeptides. 44
Pages: 431-435
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[Journal Article] Infrared radiation has potential antidepressant and anxiolytic effects in animal model of depression and anxiety.2010
Author(s)
Yoshihiro Tanaka, Jotaro Akiyoshi, Yoshinari Kawahara, Yoshinobu Ishitobi, Koji Hatano, Nobuhiko Hoaki, Ayumi Mori, Shinjiro Goto, Jusen Tsuru, Hirotaka Matushita, Hiroaki Hanada, Kensuke Kodama, Koichi Isogawa, Hirokazu Kitamura, Yoshihisa Fujikura
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Journal Title
Brain Stimulation (published online)
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[Journal Article] Elevated salivary α-amylase and cortisol levels in unremitted and remitted depressed patients.2010
Author(s)
Yoshinobu Ishitobi, Jotaro Akiyoshi, Yoshihiro Tanaka, Tomoko Ando, Shizuko Okamoto, Masayuki Kanehisa, Kentaro Kohno, Taiga Ninomiya, Yoshihiro Maruyama, Jusen Tsuru, Aimi Kawano, Hiroaki Hanada, Koichi Isogawa, Kensuke Kodama
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Journal Title
International Journal of Psychiatry in Clinical Practice. 14
Pages: 268-273
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[Journal Article] Social support and enhanced suppression of adrenocotropic hormone and cortisol responses to hypothalamic-pituitary-adrenal function and thyrotoropin-releasing hormone tests in patients with major depressive disorder.2008
Author(s)
Jusen Tsuru, Jotaro Akiyoshi, Yoshihiro Tanaka, Hirotaka Matsushita, Hiroaki Hanada, Kensuke Kodama, Takatoshi Hikichi, Hirochika Ohgami, Takashi Tsutsumi, Koichi Isogawa, Haruo Nagayama
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Journal Title
Biological Psychology. 78
Pages: 159-163
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