2010 Fiscal Year Final Research Report
Hippocampal Gene expression analysis related with redox regulation in excitatory synaptic circuit of epileptogenesis
| Project/Area Number |
20591372
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | University of Miyazaki |
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Principal Investigator |
UEDA Yuto University of Miyazaki, 医学部, 准教授 (70244192)
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| Co-Investigator(Kenkyū-buntansha) |
DOI Taku 宮崎大学, 医学部, 助教 (70274793)
NAKAJIMA Akira 宮崎大学, 医学部, 准教 (10041857)
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| Project Period (FY) |
2008 – 2010
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| Keywords | てんかん / グルタミン酸 / GABA / トランスポーター / レドックス制御 / チオレドキシン |
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| Research Abstract |
As well known the knockdown EAAC-1 by anti-sense induces epileptic convulsion in rats, EAAC-1 is important protein to connect glutamate re-uptake with GABA synthesis. It is important study to elucidate the role of glutamate transporter associated protein 3-18 (GTRAP3-18), because GTRAP3-18 inhibitory regulates the glutamate re-uptake through EAAC-1 into GABAergic neurons. Hippocampal glutamate and GABA basal release in GTRAP3-18 knockdown group higher rather than those of sense-injected group suggested knockdown of GTRAP3-18 promotes GABA synthesis. Sustenance of high seizure susceptibility in the PTZ kindled state and the existence of inter-paroxysmal period could be explained by synchronization of glutamatergic neuron caused by the enhanced GABAergic system.
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Research Products
(10 results)
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[Journal Article] Levetiracetam enhances endogenoantioxidant in the hippocampusrats : in vivo evaluation by brain microdialysis combined with ESR spectroscopy.2009
Author(s)
Ueda, Y., Doi, T., Takaki, M., Nagatomo, K., Nakajima, A., Willmore, L.J.
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Journal Title
Brain Res 1266
Pages: 1-7
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[Presentation] Affect of dissolved oxygen on the reduction of nitroxide by vitamin C : In vitro model for acute ischamia.2010
Author(s)
Nakajima, A., Masuda, Y., Matsuda, E., Ueda, Y., Sameshima, H., Ikenoue, T.
Organizer
In : APES2010.
Place of Presentation
Jeju, Korea.
Year and Date
20101010-20101014
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[Presentation] Affect of dissolved oxygen on the reduction of nitroxide by vitamin C : In vitro model for acute ischamia.2010
Author(s)
Nakajima, N., Masuda, Y., Matsuda, E., Ueda, Y., Samejima, H., Ikenoue, T.
Organizer
In : APES2010.
Place of Presentation
Jeju.
Year and Date
20101010-20101014
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[Presentation] Hippocampal gene network analysis to determine the effects of antioxidant treatment in an experimental model of accelerated senescence2010
Author(s)
Ueda, Y., Sato, A., Kitamoto, A., Adati, N., Oikawa, T., Kojima, T.
Organizer
In : Inflammation 2010.
Place of Presentation
Luxembourg.
Year and Date
2010-11-18
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