2010 Fiscal Year Final Research Report
Study on roles of neurogenesis and peripheral blood BDNF in depression.
| Project/Area Number |
20591373
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
HASHIMOTO Eri Sapporo Medical University, 医学部, 准教授 (30301401)
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| Co-Investigator(Kenkyū-buntansha) |
UKAI Wataru 札幌医科大学, 医学部, 講師 (40381256)
YAMADA Misa 国立精神・神経医療研究センター, 精神保健研究所, 研究員 (10384182)
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| Co-Investigator(Renkei-kenkyūsha) |
WATANABE Kimihiko 札幌医科大学, 医学部, 研究員 (70464493)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 神経科学 / 脳・神経 / うつ病 / 神経新生 / BDNF / 抗うつ薬 / 血小板 / 末梢血 |
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| Research Abstract |
We analyzed the influence of antidepressants on platelet BDNF release in rats. BDNF was dose-dependently released from platelets by direct treatment with various kinds of antidepressants in vitro. Sertraline-induced BDNF release from platelets was reduced in the presence of TrkB inhibitor, K252a in a rat model of depression compared with control rats. We also investigated neuroserpin expression in adult rat SGZ and found that neuroserpin may play some roles in early stage of neurogenesis in adult rat hippocampus.
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[Journal Article] Effects of antidepressants on brain- derived neurotrophic factor (BDNF) release from platelets in the rats.2010
Author(s)
Watanabe K, Hashimoto E, Ukai W, Ishii T, Yoshinaga T, Ono T, Tateno M, Watanabe I., Shirasaka T, Saito S, Saito T.
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Journal Title
Prog Neuropsychopharmacol Biol Psychiatry 34
Pages: 1450-1454
Peer Reviewed
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[Presentation] Stem cell regulation as a new treatment strategy for alcoholism and other psychiatric disorders. In : [Symposium] : Alcohol and neuropsychiatric disorders.2010
Author(s)
Saito T, Hashimoto E, Ukai W, Yoshinaga T, Ishii T, Tateno M, Ono T, Shirasaka T, Watanabe K, Watanabe I.
Organizer
In : International Society for Biomedical Research on Alcoholism
Place of Presentation
Paris, France
Year and Date
20100913-20100916
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[Presentation] Dysregulation of neurogenesis in alcohol- ism and depression : possible approach to regulate neurogenesis by anti- depressants in the damaged brain by ethanol. In : [Symposium] : Alcoholism and Depression : Possible Common Patho-physiology.2009
Author(s)
Hashimoto E, Ishii T, Ukai W, Tateno M, Yoshinaga T, Watanabe K, Ono T, Watanabe I, Shirasaka T, Saito T.
Organizer
In : The 1st Congress of Asia-Pacific Society for Alcohol and Addiction Research
Place of Presentation
Seoul, Koreae
Year and Date
20091112-20091114
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[Presentation] Potential regulation of neurogenesis by psych tropics in the damaged brain by ethanol. In :[Symposium] : Dysregulation of neu- rogenesis in the brain action : The common mechanism of alcoholism and depression.2009
Author(s)
Hashimoto E, Yoshinaga T, Ishii T, Ukai W, Tateno M, Ono T, Watanabe K, Watanabe I, Shirasaka T, Saito T.
Organizer
In : 9^<th> World Congress of Biological Psychiatry
Place of Presentation
Paris, France
Year and Date
20090628-20090702
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