2010 Fiscal Year Final Research Report
Identification of novel targets related to induce expression of neurotrophic factors at antidepressant in glia
| Project/Area Number |
20591384
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | 国立病院機構呉医療センター精神科 (2010)
Department of Clinical Research, National Hospital Organization Kure Medical Center (2008-2009) |
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Principal Investigator |
TAKEBAYASHI Minoru 国立病院機構呉医療センター精神科, 臨床研究部, 科長・室長 (60304440)
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| Co-Investigator(Kenkyū-buntansha) |
NAKATA Yoshihiro 広島大学, 薬学部, 教授 (40133152)
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| Co-Investigator(Renkei-kenkyūsha) |
HISAOKA Kazue 広島大学, 薬学部, 助教 (20393431)
OKADA Mami (土岡 麻美) 国立病院機構呉医療センター, 臨床研究部, 研究員 (30517280)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 精神薬理学 |
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| Research Abstract |
We have tried to identify the monoamine-independent novel target to antidepressant in glia. We revealed a pathway from antidepressant to expression of neurotrophic factors as follows; antidepressant→MMP activation→FGF2 shedding→FGFR1,2→ERK→CREB→expression of neurotrophic factors. This finding suggests that molecules related to activation of MMP and FGFR might be candidates of the novel targets. On the other hand, we synthesized the ligand of biotinylated antidepressant and separated the antidepressant-binding protein by using the ligand. Some bands were identified, which is being reconfirmed.
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