2010 Fiscal Year Final Research Report
Neurophysiological study on cognitive pathology of depression : relevant to anterior cingulate cortex
| Project/Area Number |
20591385
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Hokkaido University |
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Principal Investigator |
KUSUMI Ichiro Hokkaido University, 大学院・医学研究科, 准教授 (30250426)
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Katsuji 北海道大学, 病院, 助教 (70344512)
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| Research Collaborator |
KITAGAWA Nobuki 北海道大学, 病院, 助教
HASHIMOTO Naoki 北海道大学, 病院, 医員
TOYOMAKI Atsuhito 北海道大学, 大学院・医学研究科, 特任助教
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| Project Period (FY) |
2008 – 2010
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| Keywords | 精神生理学 |
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| Research Abstract |
It is possible that depressive patients have dysregulation of cognitive processes due to hyperactivity of anterior cingulate cortex. We measured feedback negativity, one of event-related brain potential and functional MRI during imposing decision-making and reward prediction problems, respectively. The amplitude of feedback negativity was decreased in schizophrenia patients compared to controls. Reward prediction induced increased neuronal activities in the dorsal anterior cingulate cortex and ventral striatum of healthy subjects using a functional MRI. Further studies are ongoing to evaluate these neurophysiological measures in depressed patients.
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Research Products
(16 results)
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[Journal Article] Depressive patients are more impulsive and inconsistent in intertemporal choice behavior for monetary gain and loss than healthy subjects--an analysis based on Tsallis' statistics.2008
Author(s)
Takahashi T, Oono H, Inoue T, Boku S, Kako Y, Kitaichi Y, Kusumi I, Masui T, Nakagawa S, Suzuki K, Tanaka T, Koyama T, Radford MH
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Journal Title
Neuroendocrinology Letters 29
Pages: 351-8
Peer Reviewed
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