2010 Fiscal Year Final Research Report
Oxidative Damage Is Associated with the Onset of Cognitive Impairment in Very Mild Alzheimer's Disease
| Project/Area Number |
20591387
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | University of Yamanashi |
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Principal Investigator |
NUNOMURA Akihiko University of Yamanashi, 大学院・医学工学総合研究部, 准教授 (60241436)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 脳神経疾患 / 認知症 / 老化 / 酸化ストレス / アルツハイマー病 / 8-hydroxyguanosine / 核酸 / 免疫細胞化学 |
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| Research Abstract |
An in situ approach was used to identify an oxidized nucleoside, 8-hydroxyguanosine in the cerebral cortex of postmortem brains. Density measurements of the immunoreactions revealed a modest but statistically significant increase in neuronal RNA oxidation during aging (0.3 to 86 years old). In the subjects with very mild Alzheimer's disease (AD), but not preclinical AD, neurons showed higher burden of oxidized RNA compared to age-matched controls. Prominent levels of neuronal RNA oxidation are associated with the earliest changes marking the onset of cognitive impairment in the prodromal stage of AD.
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