2010 Fiscal Year Final Research Report
Development of methods to promote degradation of amyloid beta
| Project/Area Number |
20591405
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Osaka University |
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Principal Investigator |
TAGAMI Shinji Osaka University, 大学院・医学系研究科, 助教 (40362735)
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| Co-Investigator(Kenkyū-buntansha) |
OKOCHI Masayasu 大阪大学, 大学院・医学系研究科, 講師 (90335357)
TAKEDA Masatoshi 大阪大学, 大学院・医学系研究科, 教授 (00179649)
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| Project Period (FY) |
2008 – 2010
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| Keywords | presenilin / gamma secretase / BACE / betaAPP / amyloid beta / Alzheimer disease |
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| Research Abstract |
Senile plaque is a pathological hallmark of Alzheimer's disease. The major component is amyloid-beta 42 (Aβ42). Inhibition of Aβ42 generation or enhancement of Aβ42 degradation is fundamental approach in developing methods to treat AD. We found that BACE, which sheds beta-amyloid protein precursor (βAPP) to generate CTF-β, cleaves Aβ42 at two sites into species with much less toxicity and hydrophobicity. We also investigated the generation mechanism of Aβ42.
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[Journal Article] The production ratios of AICDε51 and Aβ42 by intramembrane proteolysis of βAPP do not always change in parallel.2010
Author(s)
Mori K, Okochi M, Tagami S, Nakayama T, Yanagida K, Kodama TS, Tatsumi S, Fujii K, Tanimukai H, Hashimoto R, Morihara T, Tanaka T, Kudo T, Funamoto S, Ihara Y, Takeda M.
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Journal Title
Psychogeriatrics 10
Pages: 117-123
Peer Reviewed
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[Journal Article]2010
Author(s)
Hayashi N, Kazui H, Kamino K, Tokunaga H, Takaya M, Yokokoji M, Kimura R, Kito Y, Wada T, Nomura K, Sugiyama H, Yamamoto D, Yoshida T, Currais A, Soriano S, Hamasaki T, Yamamoto M, Yasuda Y, Hashimoto R, Tanimukai H, Tagami S, Okochi M, Tanaka T, Kudo T, Morihara T, Takeda M.
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Journal Title
Dement Geriatr Cogn Disord 30
Pages: 302-308
Peer Reviewed
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[Journal Article] The 28-amino acid form of an APLP1-derived Ab-like peptide is a surrogate marker for Ab42 production in the central nervous system.2009
Author(s)
Yanagida K, Okochi, M., Tagami S, Nakayama T, Kodama TS, Nishitomi K, Jiang J, Mori K, Tatsumi S, Arai T, Ikeuchi T, Kasuga K, Tokuda T, Kondo M, Ikeda M, Deguchi K, Kazui H, Tanaka T, Morihara T, Hashimoto R, Kudo T, Steiner H, Haass C, Tsuchiya K, Akiyama H, Kuwano R, Takeda M.
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Journal Title
EMBO Molecular Medicine 1
Pages: 223-235
Peer Reviewed
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[Journal Article] Destruxin E Decreases Beta-Amyloid Generation by Reducing Colocalization of Beta-Amyloid-Cleaving Enzyme 1 and Beta-Amyloid Protein Precursor.2009
Author(s)
Itoh N, Okochi, M., Tagami S, Nishitomi K, Nakayama T, Yanagida K, Fukumori A, Jiang J, Mori K, Hosono M, Kikuchi J, Nakano Y, Takinami Y, Dohi K, Nishigaki A, Takemoto H, Minagawa K, Katoh T, Willem M, Haass C, Morihara T, Tanaka T, Kudo T, Hasegawa H, Nishimura M, Sakaguchi G, Kato A, Takeda M.
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Journal Title
Neurodegenerative Dis 6
Pages: 230-239
Peer Reviewed
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[Journal Article] Impaired prepulse inhibition and habituation of acoustic startle response in Japanese patients with schizophrenia.2008
Author(s)
Takahashi H, Iwase M, Ishii R, Ohi K, Fukumoto M, Azechi M, Ikezawa K, Kurimoto R, Canuet L, Nakahachi T, Iike N, Tagami S, Morihara T, Okochi M, Tanaka T, Kazui H, Yoshida T, Tanimukai H, Yasuda Y, Kudo T, Hashimoto R, Takeda M.
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Journal Title
Neurosci Res 62
Pages: 187-194
Peer Reviewed
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[Journal Article] 0
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[Presentation] Relation between preseniln/γ -secretase modulators and Notch signaling intensity.2008
Author(s)
Tagami S, Okochi M, Yanagida K, Nakayama T, Kodama T, Tatsumi S, Jiang J, Mori KSakaguchi G, Kato A, Hasegawa H, Nishimra M, Takeda M.
Organizer
第27回日本認知症学会
Place of Presentation
群馬県前橋テルサ
Year and Date
2008-10-10
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