2010 Fiscal Year Final Research Report
Involvement of interaction between RNA and protein in neurodegenerative mechanisms in dementia
| Project/Area Number |
20591407
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Osaka University |
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Principal Investigator |
TANAKA Toshihisa Osaka University, 大学院・医学系研究科, 講師 (10294068)
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| Co-Investigator(Kenkyū-buntansha) |
TAKEDA Masatoshi 大阪大学, 医学系研究科, 教授 (00179649)
MORIHARA Takashi 大阪大学, 医学系研究科, 助教 (90403196)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 老年精神医学 |
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| Research Abstract |
To elucidate involvement of interaction between RNA and protein in neurodegenerative processes, ribotoxic stress was added by oxidative stress, and phosphorylation of tau and activation of JNK and p38 MAPK were revealed. And, TLR-3, an innate immune receptor that can bind to double stranded RNA, was also investigated in disease brain, including Alzheimer disease and amyloid-transgenic mice Tg2576. Expression of TLR-3 was significantly increased in Alzheimer disease and Tg2576, and TLR-3 positive cells were distributed in and around amyloid plaques. In these neurodegenerative processes, oxidation of rRNA or release of RNA from dead cells, might be involved.
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[Journal Article] The production ratios of AICDε51 and Aβ42 by intra- membrane proteolysis of βAPP do not always change in parallel.2010
Author(s)
Mori K, Okochi M, Tagami S, Nakayama T, Yanagida K, Kodama TS, Tatsumi S, Fujii K, Tanimukai H, Hashimoto R, Morihara T, Tanaka T, Kudo T, Funamoto S, Ihara Y, Takeda M.
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Journal Title
Psychogeriatrics. 10(3)
Pages: 117-123
Peer Reviewed
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[Journal Article] KIBRA genetic polymorphism influences episodic memory in Alzheimer's disease, but does not show association with disease in a Japanese cohort.2010
Author(s)
Hayashi N, Kazui H, Kamino K, Tokunaga H, Takaya M, Yokokoji M, Kimura R, Kito Y, Wada T, Nomura K, Sugiyama H, Yamamoto D, Yoshida T, Currais A, Soriano S, Hamasaki T, Yamamoto M, Yasuda Y, Hashimoto R, Tanimukai H, Tagami S, Okochi M, Tanaka T, Kudo T, Morihara T, Takeda M.
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Journal Title
Dement Geriatr Cogn Disord. 30(4)
Pages: 302-308
Peer Reviewed
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[Journal Article] Destruxin E Decreases Beta-Amyloid Generation by Reducing Colocalization of Beta-Amyloid-Cleaving Enzyme 1 and Beta-Amyloid Protein Precursor.2009
Author(s)
Itoh N, Okochi M, Tagami S, Nishitomi K, Nakayama T, Yanagida K, Fukumori A, Jiang J, Mori K, Hosono M, Kikuchi J, Nakano Y, Takinami Y, Dohi K, Nishigaki A, Takemoto H, Minagawa K, Katoh T, Willem M, Haass C, Morihara T, Tanaka T, Kudo T, Hasegawa H, Nishimura M, Sakaguchi G, Kato A, Takeda M.
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Journal Title
Neurodegener Dis 6
Pages: 230-239
Peer Reviewed
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[Journal Article] Dynamin 2 gene is a novel susceptibility gene for late-onset Alzheimer disease in non-APOE-epsilon4 carriers.2008
Author(s)
Aidaralieva NJ, Kamino K, Kimura R, Yamamoto M, Morihara T, Kazui H, Hashimoto R, Tanaka T, Kudo T, Kida T, Okuda J, Uema T, Yamagata H, Miki T, Akatsu H, Kosaka K, Takeda M.
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Journal Title
J Hum Genet. 53
Pages: 296-302
Peer Reviewed
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[Presentation] PIB-PET images, compared with MR, FDG-PET, IMP-SPECT images, of a patient with Alzheimer's disease with presenilin-1 mutation (Met233Leu) showing a new phenotype.2010
Author(s)
Takaya M, Tanaka T, Ataka S, Shimada H, Morihara T, Miki T, Kazui H, Takeda M
Organizer
The 13^<th> International Conference on Alzheimer Disease and related disorders
Place of Presentation
Hawaii, U.S.A.
Year and Date
20100710-20100715
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[Presentation] Identification of a gene which controls Abeta accumulation using App Tg mice with mixed genetic background2010
Author(s)
Morihara T, Hayashi N, Yokokoji M, Fukusyo E, Tanimukai H, Tagami S, Okochi M, Tanaka T, Kudo T, Takeda M
Organizer
The 13^<th> International Conference on Alzheimer Disease and related disorders
Place of Presentation
Hawaii, U.S.A.
Year and Date
20100710-20100715
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