2010 Fiscal Year Final Research Report
The neural substrate of stereotypic behaviors in patients with frontotemporal dementia
| Project/Area Number |
20591414
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Kumamoto University |
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Principal Investigator |
IKEDA Manabu Kumamoto University, 大学院・生命科学研究部, 教授 (60284395)
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| Co-Investigator(Kenkyū-buntansha) |
HASHIMOTO Mamoru 熊本大学, 医学部附属病院, 助教 (20452881)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 常同行動 / FTD / 神経基盤 / 統計画像解析 / SPECT / 食行動 / Semantic Dementia / Progressive supranuclear palsy |
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| Research Abstract |
Recently, the relationship between Progressive supranuclear palsy (PSP) and frontotemporal dementia (FTD) has been recognized, which includes clinical, pathological, biochemical and genetic features. However, there have been few studies that directly compared neuropsychiatric symptoms between PSP and FTD. The aim of the present study was to investigate comprehensive psychiatric and behavioral symptoms in PSP and compared them with those in FTD. Patients with PSP (n=10) and FTD (n=13) were selected on the basis of inclusion/exclusion criteria from a consecutive series in the dementia clinic of Kumamoto University Hospital. We assessed their comprehensive neuropsychiatric features by using the Neuropsychiatric Inventory (NPI), the Stereotypy Rating Inventory (SRI) and a specific antisocial behavior checklist. There were no significant differences in the total NPI and NPI subscale scores between the two groups. Both groups showed quite asimilar pattern in the features of neuropsychiatric symptoms : apathy showed the highest score, followed by aberrant motor behavior and disinhibition.
The PSP group was significantly lower in the total SRI and eating and cooking behavior scores than those in the FTD group. The prevalence of antisocial behaviors in PSP (50%) was equal to those in the FTD group (46%). We hypothesize that the stereotypic behaviors reflect the involvement of specific neural substrate in FTD-namely, the ventral frontal lobe, the temporal pole, and the amygdala.
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[Journal Article] Clinical profiles of Late-onset Semantic Dementia, compared with Early-onset Semantic Dementia and Late-onset Alzheimer's Disease.2011
Author(s)
Shimizu H, Komori K, Fukuhara R, Shinagawa S, Toyota Y, Kashibayashi T, Sonobe N, Matsumoto T, Mori T, Ishikawa T, Hokoishi K, Tanimukai S, Ueno S, Ikeda M.
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Journal Title
Psychogeriatrics 11
Pages: 46-53
Peer Reviewed
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[Journal Article] Risk of progression from mild memory impairment to clinically diagnosable Alzheimer disease in a Japanese community (from the Nakayama Study).2011
Author(s)
Sonobe N, Hata R, Ishikawa T, Sonobe K, Matsumoto T, Toyota Y, Mori T, Fukuhara R, Komori K, Ueno S, Tanimukai S, Ikeda M.
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Journal Title
International Psychogeriatrics 23
Pages: 772-779
Peer Reviewed
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[Journal Article] Transition of distinctive symptoms of semantic dementia during longitudinal clinical observation.2010
Author(s)
Kashibayashi T, Ikeda M., Komori K, Shinagawa S, Shimizu H, Toyota Y, Mori T, Ishikawa T, Fukuhara R, Ueno S, Tanimukai S.
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Journal Title
Dement Geriatr Cogn Disord 29
Pages: 224-232
Peer Reviewed
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[Presentation] Distinction of inferior temporal atrophy in semantic dementia and Alzheimer's disease by MRI visual inspection.2010
Author(s)
Fukuhara R, Mori T, Tanimukai S, Komori K, Matsumoto T, Toyota Y, Kashibayashi T, Shimizu H, Sonobe N, Kitamura I, Ueno S, Ikeda M.
Organizer
7^<th> International Conference on Frontotemporal Dementias
Place of Presentation
Indianapolis, USA
Year and Date
20101006-20101008
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[Presentation] Transition of distinctive symptoms of semantic dementia during longitudinal clinical observation.2009
Author(s)
Kashibayashi T, Ikeda M, Komori K, Shinagawa S, Shimizu H, Toyota Y, Mori T, Ishikawa T, Fukuhara R, Ueno S, Tanimukai S.
Organizer
IPA 14^<th> International congress
Place of Presentation
Montreal
Year and Date
20090901-20090905
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