Enhancement effects of angiotensin II on amyloid 3-induced axonal impairment

2010 Fiscal Year Final Research Report

• Project/Area Number: 20591418
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Kitasato University
• Principal Investigator: HIRUMA Hiromi Kitasato University, 医学部, 准教授 (10238397)
• Project Period (FY): 2008 – 2010
• Keywords: アンギオテンシンII / アミロイドβ蛋自 / 軸索障害 / 軸索輸送

Research Abstract

Amyloid (3 protein (A(3), a causal agent of Alzheimer's disease,damages axons of neurons through actin polymerization. The present study investigated the modifying effects of angiotensin II (AngII), a vasoconstrictive hormone, on A(3 action and obtained the following results. 1) Similar to A(3, AngII decreased axonal transport and constricted axons. These effects are mediated by AngII AT1 receptors and actin polymerization. 2) AngIl enhanced the A1-induced inhibition of axonal transport and constriction of axons. Therefore, AngII is suggested to enhance A(3-induced impairment of axons via actin polymerization.

Research Products

• [Journal Article] Characteristics of weak base-induced vacuoles formed around individual acidic organelle. (2011)
  • Author(s): Hiruma H, Kawakami T
  • Journal Title: Folia Histochem Cytobiol (in press)
  • Peer Reviewed
• [Journal Article] Inhibition of Axonal Transport Caused by tert-Butyl Hydroperoxide in Cultured Mouse Dorsal Root Ganglion Neurons. (2010)
  • Author(s): Isonaka R, Hiruma H, Kawakami T
  • Journal Title: J Mol Neurosci (in press)
  • Peer Reviewed
• [Journal Article] Rapid inhibitory effect of progesterone on axonal transport in isolated and cultured mouse dorsal root ganglion neurons. (2010)
  • Author(s): Katakura T, Hiruma H, Isonaka R, Kawakami T
  • Journal Title: The Kitasato Medical Journal 40 Pages: 12-19
  • Peer Reviewed
• [Journal Article] Effects of 4-aminopyridine on organelle movement in cultured mouse dorsal root ganglion neurites. (2010)
  • Author(s): Hiruma H, Kawakami T
  • Journal Title: J Mol Neurosci 40(3) Pages: 295-302
  • Peer Reviewed
• [Journal Article] Spinal procaine is less neurotoxic than mepivacaine, prilocaine and bupivacaine in rats. (2009)
  • Author(s): Takenami T, Yagishita S, Nara Y, Tsai YH, Hiruma H, Kawakami T, Hoka S
  • Journal Title: Reg Anesth Pain Med 34(3) Pages: 189-195
  • Peer Reviewed
• [Journal Article] Effects of clonidine on lidocaine-induced inhibition of axonal transport in cultured mouse dorsal root ganglion neurones. (2008)
  • Author(s): Hiruma H, Shimizu K, Takenami T, Sugie H, Kawakami T
  • Journal Title: Br J Anaesth 101(5) Pages: 659-665
  • Peer Reviewed
• [Journal Article] Clonidine prevents neurotoxic effects of lidocaine in culutred mouse dorsal root gang ; lion neurons. (2008)
  • Author(s): Shimizu K, Hiruma H, Kawakami T, Hoka S
  • Journal Title: The Kitasato Medical Journal 38 Pages: 37-46
  • Peer Reviewed
• [Presentation] Amyloid-ss protein-actin complex is more neurotoxic than amyloid-I3 protein alone. (2009)
  • Author(s): Hiruma H, Katakura T, Kawakami T
  • Organizer: XXXVI International Congress of Physiological Sciences (IUPS2009)
  • Place of Presentation: 京都
  • Year and Date: 2009-08-01
• [Presentation] Effects of amyloid-ss protein-actin complex on axonal transport in cultured rat hippocampal neurons. (2008)
  • Author(s): Hiruma H, Katakura T, Kawakami T
  • Organizer: Neuroscience 2008.
  • Place of Presentation: ワシントン(米国)
  • Year and Date: 2008-11-19
• [Presentation] Angiotensin II enhances amyloid ss-protein-induced impairment of axonal transport. (2007)
  • Author(s): Hiruma H, Katakura T, Kawakami T
  • Organizer: Neuroscience 2007.
  • Place of Presentation: サンジエゴ(米国)
  • Year and Date: 2007-11-06