The relationship between the effect of rehabilitation and loss of neuronal integrity in patients with brain injury.

2010 Fiscal Year Final Research Report

• Project/Area Number: 20591429
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Hokkaido University
• Principal Investigator: SHIGA Tohru Hokkaido University, 大学院・医学研究科, 講師 (80374495)
• Co-Investigator(Kenkyū-buntansha): IKOMA Katsunori 北海道大学, 病院, 教授 (70202918) ; TERAE Satoshi 北海道大学, 病院, 准教授 (40240634) ; KATOH Chietsugu 北海道大学, 大学院・保健科学研究院, 准教授 (10292012) ; KUGE Yuji 北海道大学, アイソトープ総合センター, 教授 (70321958)
• Project Period (FY): 2008 – 2010
• Keywords: 核医学(PETを含む) / 頭部外傷

Research Abstract

One of the aims was to analyze the sequential and spatial change of benzodiazepine receptor density, metabolism, neuronal integrity using molecular imaging such as SPECT and PET. To clarify the sequential change, we investigate the reconstruction and analyzing method for animal C-11 flumazenil using animal PET/SPECT/CT. We developed a new method for analyzing binding potential of C-11 flumazenil using rat model. Another aim was to investigate the relationship between effect of rehabilitation and neuronal integrity in patients with brain injury. First we studied the relationship between C-11 flumazenil PET findings and I-123 Iomazenil SPECT findings. Our study indicated that although IMZ SPECT has slightly lower contrast than FMZ PET, IMZ SPECT could detect loss of neuronal integrity as almost same as FMZ PET. Second, we investigate the relationship among metabolic change, loss of neuronal integrity and effect of rehabilitation. However, we could not find the relationship among those parameters.

Research Products

• [Journal Article] Semiquantitative analysis of C-11 methionine PET may distinguish brain tumor recurrence from radiation necrosis even in small lesions. (2011)
  • Author(s): Okamoto S, Shiga T, Hattori N, Kubo N, Takei T, Katoh N, Sawamura Y, Nishijima,K, Kuge Y, Tamaki N.
  • Journal Title: Ann Nucl Med. 25(3) Pages: 213-20
  • Peer Reviewed
• [Journal Article] A new PET scanner with semiconductor detectors enables better identification of intratumoral inhomogeneity. (2009)
  • Author(s): Shiga T, Morimoto Y, Kubo N, Katoh N, Katoh C, Takeuchi W, Usui R, Hirata K, Kojima S, Umegaki K, Shirato H, Tamaki N.
  • Journal Title: J Nucl Med.
  • Peer Reviewed
• [Journal Article] flumazenil positron emission tomography analyses of brain gamma-aminobutyric acid type A receptors in Angelman syndrome. (2008)
  • Author(s): Asahina N, Shiga T, Egawa K, Shiraishi H, Kohsaka S, Saitoh S.
  • Journal Title: J Pediatr. 152(4) Pages: 549(546-9)
  • Peer Reviewed
• [Presentation] 頭部外傷患者におけるIMZ SPECTとFMZ PETとの比較 (2010)
  • Author(s): 志賀哲、生駒一憲、臼居礼子、平田健司、服部直哉、加藤千恵次、久下祐司、玉木長良
  • Organizer: 第50回日本核医学会総会
  • Place of Presentation: 大宮
  • Year and Date: 20101111-20101113
• [Presentation] I-123 IMZ SPECT may detect loss of neuronal integrity in patients with traumatic brain injury. (2010)
  • Author(s): Tohru Shiga, Katsunori Ikoma, Reiko Usuil, Kenji Hirata, Naoya Hattori, Yuji Kuge, Satoshi Terae, Nagara Tamaki
  • Organizer: The 57th Annual Meeting, Society of nuclear medicine.
  • Place of Presentation: Salt lake city
  • Year and Date: 20100605-20100609
• [Presentation] 頭部外傷患者におけるIMZ SPECTとFMZ PETとの比較 (2010)
  • Author(s): 志賀哲、生駒一憲、臼居礼子、平田健司、服部直哉、加藤千恵次、久下祐司、玉木長良
  • Organizer: 第122回日本医学放射線学会 北日本地方会
  • Place of Presentation: 仙台
  • Year and Date: 2010-06-25
• [Remarks] ホームページ等