2010 Fiscal Year Final Research Report
Development of the integrated system for the analysis of brain function by high resolution micro-PET for small animals using high field MRI
| Project/Area Number |
20591434
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
MOMOSE Toshimitsu The University of Tokyo, 医学部附属病院, 准教授 (20219992)
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| Co-Investigator(Kenkyū-buntansha) |
SEKINO Masaki 東京大学, 工学系研究科, 講師 (20401036)
KOJIMA Yoshiki 国立がんセンター, がん研究所, 研究員 (20167357)
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| Project Period (FY) |
2008 – 2010
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| Keywords | micro-PET / high field MRI / small animal / brain imaging / molecular imaging |
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| Research Abstract |
The high-resolution PET for small animals is expected to be one of the important tools for the elucidation of the pathophysiology and the innovative drug development of the disease. In this study, we tried to develop the system which enables us to analyze molecular target imaging by micro-PET using high-field MRI. We attempted to design a new head fixation device for mouse which can be used commonly both for micro-PET and high-field MRI for small animals, and made a digital mouse brain atlas for anatomic delineation on micro-PET imaging and MRI utilizing an atlas of stained brain sections of mice, on which each brain domain was separated by color. We applied this technique to the analysis of FDG-PET imaging of normal and transgenic mouse. The abnormal metabolic area on the FDG-PET image of the disease model mouse (DRPLA) was successfully identified using our newly developed system.
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[Journal Article] Conventional allogeneic hematopoietic stem cell transplantation for lymphoma may overcome the poor prognosis associated with a positive FDG-PET scan before transplantation.2008
Author(s)
Yoshimi A, Izutsu K, Takahashi M, Kako S, Oshima K, Kanda Y, Motokura T, Chiba S, Momose T, Ohtomo K, Kurokawa, M
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Journal Title
Am J Hematol 83
Pages: 477-481
Peer Reviewed
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[Remarks] ホームページ等
