2010 Fiscal Year Final Research Report
Contrast enhancement of pancreatic carcinoma on dynamic CT : correlation between expression of VEGF and histopathological features
| Project/Area Number |
20591436
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kanazawa University |
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Principal Investigator |
GABATA Toshifumi Kanazawa University, 医学系, 准教授 (00169806)
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| Project Period (FY) |
2008 – 2010
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| Keywords | エックス線 / CT / 膵管癌 |
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| Research Abstract |
To evaluate retrospectively the correlation between enhancement patterns on dynamic computed tomography (CT) and angiogenesis and fibrosis in pancreatic adenocarcinoma. The tumors with greater MVD and higher expression of VEGF tended to show high enhancement in the arterial dominant phase. On the other hand, the tumors with a larger amount of fibrosis showed a negative correlation with the grade of enhancement during the arterial phase. In conclusion, enhancement patterns on dynamic CT correlated with angiogenesis and may be modified by the extent of fibrosis.
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