Interstitial pathological change and its imaging in myocardial ischemia and remodeling

2010 Fiscal Year Final Research Report

• Project/Area Number: 20591437
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kanazawa University
• Principal Investigator: TAKI Junichi Kanazawa University, 附属病院, 講師 (10251927)
• Co-Investigator(Kenkyū-buntansha): SIBA Kazuhiro 金沢大学, 学際科学実験センター, 教授 (40143929) ; OGAWA Kazuma 金沢大学, 薬学系, 准教授 (30347471)
• Project Period (FY): 2008 – 2010
• Keywords: tenascin-C / matricellular蛋白 / リモデリング / 心筋梗塞 / 虚血 / 再還流

Research Abstract

Tenascin-C(TNC) expression was examined by autoradiography using I-125-anti-TNC-Ab (I-TNC) in a rat model of myocardial ischemia and reperfusion. I-TNC accumulation was observed in the ischemic area and its accumulation was peaked at day 3 and decreased at day 7-14 and only faint uptake was observed at day 28. Postconditioning mildly suppressed TNC expression at day 3-7 but significantly at day 14.

Research Products

• [Journal Article] Dynamic expression of tenascin-c after myocardial ischemia and reperfusion : Assessment by 125I-anti-tenascin-c antibody imaging. (2010)
  • Author(s): Taki, J., Inaki, A., Wakabayashi, H., Imanaka-Yoshida, K., Ogawa, K., Hiroe, M., Shiba, K., Yoshida, T., Kinuya, S.
  • Journal Title: J Nucl Med 51 Pages: 1116-1122
  • Peer Reviewed
• [Journal Article] Potential utility of 99mTc-annexin V imaging in ischemically damaged myocardium. (2010)
  • Author(s): Taki, J., Matsunari, I., Wakabayashi, H., Inaki, A., Kinuya, S.
  • Journal Title: Intv Cariol 2 Pages: 765-767
  • Peer Reviewed
• [Presentation] Detection of ischemia and apoptosis in the diseased myocardium. (2010)
  • Author(s): Taki, J.
  • Organizer: World Molecular Imaging Congress 2010.
  • Place of Presentation: Kyoto International Conference Center (Kyoto)
  • Year and Date: 2010-09-08
• [Presentation] Temporal change of Tnascin-C expression in a rat model of moderate and severe ischemia : Assessment by I-125-anti tenascin-C antibody imaging. (2010)
  • Author(s): Taki, J., Wakabayashi, H., Inaki, A., Imanaka-Yoshida, K., Ogawa, K., Shiba, K., Hiroe, M., Nakajima, K., Matsuo, S., Kinuya, S.
  • Organizer: 57th Annual Meeting of the Society of Nuclear Medicine.
  • Place of Presentation: Salt Place Convention Center (USA)
  • Year and Date: 2010-06-08
• [Presentation] Temporal assessment of Tnascin-C expression in a rat model of myocardial ischemia and reperfusion. (2009)
  • Author(s): Taki, J., Inaki, A., Wakabayashi, H., Ogawa, K., Shiba, K., Hiroe, M., Imanaka-Yoshida, K., Kayano, D., Nakajima, K., Kinuya, S.
  • Organizer: 56th Annual Meeting of the Society of Nuclear Medicine.
  • Place of Presentation: Toronto Convention Center (Canada)
  • Year and Date: 2009-06-15
• [Book] 臨床医とコメディカルのための最新クリニカルPET (2010)
  • Author(s): 滝淳一
  • Total Pages: 283-287
  • Publisher: 先端医療技術研究所