Assessment of liver fibrosis with cine-tagging MR imaging

2010 Fiscal Year Final Research Report

• Project/Area Number: 20591439
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Gifu University
• Principal Investigator: WATANABE Haruo Gifu University, 医学部附属病院, 医員 (30456529)
• Co-Investigator(Kenkyū-buntansha): KANEMATSU Masayuki 岐阜大学, 医学部附属病院, 准教授 (40252134) ; GOSHIMA Satoshi 岐阜大学, 医学部附属病院, 助教 (90402205) ; KONDO Hiroshi 岐阜大学, 医学部附属病院, 講師 (20324311) ; FUJITA Hiroshi 岐阜大学, 医学系研究科, 教授 (10124033) ; TSUGE Yuusuke 岐阜大学, 医学部附属病院, 医員 (80444272)
• Project Period (FY): 2008 – 2010
• Keywords: MR imaging / 肝線維症 / 3T / Elastography / Cine-tagging

Research Abstract

Objective : To preliminary evaluate the feasibility and usefulness of MR elastography (MRE) of the liver at 3 T with cine-tagging and bending energy (BE) analysis for the evaluation of hepatic fibrosis. Materials and Methods : Twenty-two patients underwent MRE with four different cine-tagging grids on the liver (16- or 20-mm sagittal or coronal). Nine images serially obtained during 1-second exhalation were analyzed to define coordinates of grid intersections. BE values were calculated using thin-plate spline method. BE values were compared among patient groups with different fibrosis stage thresholds. Results : In 22 patients, six had fibrosis score of F0, one had F1, seven had F2, three had F3, and five had F4. Mean BE value with 16-mm sagittal grid was greater with fibrosis score F0 (1.54±0.63) than with〓F1 (0.97±0.12, P=.013) as well as with〓F1 (1.48±0.60) than with〓F2 (0.96±0.36, P=.019). Conclusion : Our results showed that MR elastography with 16-mm sagittal grid and BE analysis had a potential in discrimination of patients with moderate or advanced hepatic fibrosis from those with healthy liver or slight fibrosis.

Research Products

• [Journal Article] MR elastography of the liver at 3 T with tine-tagging and bending energy analysis : preliminary results. (2010)
  • Author(s): Watanabe H, Kanematsu M, Kitagawa T, Suzuki Y, Kondo H, Goshima S, Kajita K, Bae KT, Hires, Miotani S, Zhou X, Fujita H.
  • Journal Title: Ear Radiol 20 Pages: 2381-2389
  • Peer Reviewed
• [Presentation] MR Elastography of the Liver with Cine-Tagging and Bending Energy Analysis Using 3T MRI : Preliminary Results. (2009)
  • Author(s): 渡邊春夫, 兼松雅之, 近藤浩史, 五島聡, 北川輝彦, 藤田廣志
  • Organizer: 第95回北米放射線学会
  • Place of Presentation: シカゴ
  • Year and Date: 2009-12-02
• [Presentation] 3T Cine-tagging MR ImagingによるMR elastography (2009)
  • Author(s): 渡邊春夫, 兼松雅之, 近藤浩史, 五島聡, 梶田公博, 北川輝彦, 美尾谷成貴, 周向栄, 藤田廣志
  • Organizer: 第4回肝癌治療シミュレーション研究会
  • Place of Presentation: 神戸
  • Year and Date: 2009-09-19
• [Presentation] 3T Cine-taggingとbending energy解析によるMR elastography (2009)
  • Author(s): 渡邊春夫, 兼松雅之, 近藤浩史, 五島聡, 柘植裕介, 梶田公博, 横山龍二郎, 北川輝彦, 周向栄, 藤田廣志
  • Organizer: 第68回日本医学放射線学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-04-18
• [Presentation] MR Elastography of the Liver with Cine-Tagging and Physical Bending Energy Analysis using 3T MRI : Phantom Study and Preliminary Clinical Application. (2008)
  • Author(s): 渡邊春夫, 兼松雅之, 近藤浩史, 五島聡, 北川輝彦, 藤田廣志
  • Organizer: 第94回北米放射線学会
  • Place of Presentation: シカゴ
  • Year and Date: 20080000
• [Presentation] 3T Cine-taggingとbending energy解析によるMR elastography (2008)
  • Author(s): 渡邊春夫, 兼松雅之, 近藤浩史, 五島聡, 柘植裕介, 梶田公博, 横山龍二郎, 北川輝彦, 周向栄, 藤田廣志
  • Organizer: 第36回日本磁気共鳴医学会大会
  • Place of Presentation: 旭川
  • Year and Date: 2008-09-11
• [Presentation] Cine-taggingとphysical bending energy(PBE)解析による肝MR elastQgraphy(MRE) (2008)
  • Author(s): 渡邊春夫、兼松雅之、近藤浩史、五島聡、北川輝彦、藤田廣志
  • Organizer: 日本医学放射線学会第144回中部地方会
  • Place of Presentation: 福井
  • Year and Date: 2008-07-12
• [Remarks] ホームページ等