2010 Fiscal Year Final Research Report
Synthesis and Clinical Study of Diagnostic Radiopharmaceuticals labeled 18Fluorine for well differentiated carcinomas.
| Project/Area Number |
20591450
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kumamoto University |
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Principal Investigator |
TOMIYOSI Katsumi Kumamoto University, 生命科学研究部, 教授 (60188802)
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| Co-Investigator(Renkei-kenkyūsha) |
ANDO Yukio 熊本大学, 生命科学研究部, 教授 (20253742)
TOMIGUCHI Seiji 熊本大学, 生命科学研究部, 教授 (20172182)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 核医学 / PET / 腫瘍検索剤 |
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| Research Abstract |
18F-Acetate (18FAC) was synthesized with a new method. After injection of 185MBq 18FAC into Volunteers, PET and CT imaging were obtained. There is not specially trapped tissues but 18FAC was metabolized and cleared through kidney to bladder. We found also no free 18Fluorine de-ionize in vivo during the measurement. More studies need to get bio-distribution experiments for normal and tumor-mounted animals.
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