2010 Fiscal Year Final Research Report
Analyses of catecholamine system in depression and schizophrenia by using neuromelanin magnetic resonance imaging
| Project/Area Number |
20591458
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Iwate Medical University |
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Principal Investigator |
SASAKI Makoto Iwate Medical University, 医学部, 教授 (80205864)
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| Co-Investigator(Kenkyū-buntansha) |
TOHYAMA Koujiro 岩手医科大学, 医学部, 教授 (10129033)
OTSUKA Kotaro 岩手医科大学, 医学部, 講師 (00337156)
SAKAI Akio 岩手医科大学, 医学部, 教授 (30146063)
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| Project Period (FY) |
2008 – 2010
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| Keywords | MRI / 神経メラニン / うつ病 / 統合失調症 / カテコラミン / 黒質 / 青斑核 |
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| Research Abstract |
We investigated signal changes in catecholamine nuclei of the brain stem by using neuromelanin- sensitive magnetic resonance imaging (MRI). In the depressive patients, signal intensity of the locus ceruleus was attenuated as compared with schizophrenic patients and healthy controls with high sensitivity and specificity, suggesting hypofunction of the noradrenergic system. In schizophrenia, signals from the substantia nigra pars compacta tended to be augmented and those from the ventral tegmental area tended to be reduced, suggesting dysfunction of the dopaminergic system. Neuromelanin MRI is a promising technique to elucidate functional changes in the catecholamine neurons of the brain stem that occur in psychiatric diseases.
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Research Products
(20 results)
