2010 Fiscal Year Final Research Report
Susceptibility-weighted MR imaging in misery perfusion in patients with ischemic cerebrovascular disease: comparison with 15O PET
| Project/Area Number |
20591467
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Research institute for Brain and Blood Vesseis Akita |
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Principal Investigator |
KINOSHITA Toshibumi Research institute for Brain and Blood Vesseis Akita, 放射線医学研究部, 部長 (70314599)
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| Co-Investigator(Kenkyū-buntansha) |
IBARAKI Masanobu 秋田県立脳血管研究センター(研究部門), 放射線医学研究部, 主任研究員 (40360359)
SHINOHARA Yuki 秋田県立脳血管研究センター(研究部門), 放射線医学研究部, 流動研究員 (60462470)
KINOSHITA Fumiko 秋田県立脳血管研究センター(研究部門), 放射線医学研究部, 主任研究員 (50304225)
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| Project Period (FY) |
2008 – 2010
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| Keywords | MRI / 磁化率強調像 / PET / 酸素摂取率 / ペナンブラ |
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| Research Abstract |
In 30 of the 37 patients with misery perfusion detected by ^<15>O PET, susceptibility-weighted MR imaging demonstrated prominently hypointense signal within the superficial and deep cerebral veins ipsilaterally in steno-occlusive lesions. None of the 24 patients without misery perfusion detected by ^<15>O PET showed prominently hypointense signal within the cerebral veins. Susceptibility-weighted imaging was superior to GRE-EPI for visualization of the prominently hypointense cerebral veins with increased deoxyhemoglobin concentration. Our results suggest that susceptibility-weighted imaging is helpful in identifying misery perfusion in chronic cerebrovascular disease.
On GRE-EPI, engorgement of superficial and deep cerebral veins was frequently seen ipsilaterally in evolving infarction due to acute embolic occlusion.
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