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2011 Fiscal Year Final Research Report

Study on diagnosis of early Alzheimer's disease by β-amyloid imaging(BF227).

Research Project

  • PDF
Project/Area Number 20591470
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionAichi Shukutoku University (2009-2011)
National Institute for Longevity Sciences,NCGG (2008)

Principal Investigator

MAENO Nobuhisa  愛知淑徳大学, 健康医療科学部, 准教授 (90463207)

Co-Investigator(Kenkyū-buntansha) KATO Takashi  国立長寿医療研究センター, 脳機能画像診断開発部・分子画像開発室, 室長 (60242864)
ITO Kengo  国立長寿医療研究センター, 脳機能画像診断開発部, 部長 (70184653)
HATANO Kentaro  国立長寿医療研究センター, 脳機能画像診断開発部・分子探索開発室, 部長 (50228475)
Project Period (FY) 2008 – 2011
Keywords核医学(PETを含む) / アルツハイマー病 / アミロイドイメージング
Research Abstract

The subjects were 15 cognitively normal subjects(NL), 20 patients with mild cognitive impairment(MCI) and 21 patients with Alzheimer disease(AD) recruited in Tohoku University. They underwent BF227-PET, 3D-MRI, and neuropsychological examination. The gray matter volume on VBM-MRI was lowest in the AD, followed by MCI, and NL. It has been suggested that this results correspond in each stage in the development of AD. In contrast, as for Aβ deposition on BF227-PET, AD and MCI showed significantly higher accumulation than NL. No significant differences were observed between AD and MCI in the Aβ deposition. The fact suggests that the Aβ deposition already reached a plateau in a stage of MCI. Moreover, in the relation with neuropsychological examination, gray matter loss may influence the cognitive function, however, the Aβ deposition may not influence the cognitive function at least in AD onset.

  • Research Products

    (22 results)

All 2011

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (17 results)

  • [Journal Article] パーキンソン病の核医学診断,特集2 :パーキンソン病とアルツハイマー病の画像診断2011

    • Author(s)
      新畑豊, 加藤隆司
    • Journal Title

      RadFan

      Volume: 9(5) Pages: 45-47

    • Peer Reviewed
  • [Journal Article] 誌上ディベートアルツハイマー病の早期診断に有用なのは形態画像か?脳血流・代謝画像か?形態画像が有用との立場から2011

    • Author(s)
      加藤隆司
    • Journal Title

      Cognition and Dementia

      Volume: 10 Pages: 68-70

    • Peer Reviewed
  • [Journal Article] FDG-PETによる認知症診断: 3D-SSPとAD t-sum.特集2 :認知症診断における統計画像2011

    • Author(s)
      加藤隆司, 山田貴史, 藤原謙, 伊藤健吾
    • Journal Title

      PETジャーナル

      Volume: Summer(14) Pages: 23-25

    • Peer Reviewed
  • [Journal Article] 認知症診断に用いられるバイオマーカー各論脳血流シンチグラフィーIn認知症学上-その解明と治療の最新知見-2011

    • Author(s)
      伊藤健吾, 加藤隆司
    • Journal Title

      日本臨床

      Volume: 69(suppl 8) Pages: 515-519

    • Peer Reviewed
  • [Journal Article] アミロイドイメージングの最近の治験と将来展望2011

    • Author(s)
      伊藤健吾, 川嶋将司, 加藤隆司
    • Journal Title

      特集2次世代のクリニカルPET

      Volume: 9(11) Pages: 59-61

    • Peer Reviewed
  • [Presentation] 自発脳磁図を用いた脳内ネットワーク機能評価によるアルツハイマー病補助診断の可能性2011

    • Author(s)
      中村昭範, 吉山顕次, Diers Kersten, 加藤隆司, 服部英幸, 文堂昌彦, 伊藤健吾
    • Organizer
      第30回認知症学会学術集会
    • Place of Presentation
      タワーホール船堀東京
    • Year and Date
      2011-11-12
  • [Presentation] NCGG memory clinic, J-ADNI。BF-227 PETにおける参照領域設定法の検討2011

    • Author(s)
      藤原謙, 加藤隆司, 伊藤健吾, 籏野健太郎, 岡村信行, 谷内一彦
    • Organizer
      第30回認知症学会学術集会
    • Place of Presentation
      タワーホール船堀東京
    • Year and Date
      2011-11-11
  • [Presentation] SEAD-J Study Group. MCI患者3年後追跡時におけるMRI灰白質密度の検討2011

    • Author(s)
      大石直也, 福山秀直, 伊藤健吾
    • Organizer
      第30回認知症学会学術集会
    • Place of Presentation
      タワーホール船堀東京
    • Year and Date
      2011-11-11
  • [Presentation] PiB陽性,陰性aMCIにおける局所糖代謝の検討2011

    • Author(s)
      高橋竜一, 石井一成, 石井賢二, 加藤隆司, 千田道雄, 伊藤健吾, 杉下守弘, 岩坪威
    • Organizer
      第30回認知症学会学術集会
    • Place of Presentation
      タワーホール船堀東京
    • Year and Date
      2011-11-11
  • [Presentation] PiB陽性aMCIにおけるApoE e4のPiB集積や局所糖代謝への効果2011

    • Author(s)
      高橋竜一, 石井一成, 石井賢二, 加藤隆司, 千田道雄, 伊藤健吾, 杉下守弘, 岩坪威
    • Organizer
      第30回認知症学会学術集会
    • Place of Presentation
      タワーホール船堀東京
    • Year and Date
      2011-11-11
  • [Presentation] もの忘れ外来グループ。[C-11] BF-227集積と脳糖代謝変動の関係:認知機能正常から健忘型MCIまで2011

    • Author(s)
      加藤隆司, 伊藤健吾, 籏野健太郎, 藤原謙, 中村昭範, 三浦久幸, 服部英幸, 新畑豊, 鷲見幸彦, 岡村信行, 谷内一彦
    • Organizer
      第30回認知症学会学術集会
    • Place of Presentation
      タワーホール船堀東京
    • Year and Date
      2011-11-11
  • [Presentation] 健常, MCI,アルツハイマー病におけるβアミロイドの集積と局所脳萎縮との関係: BF227-PETとMRIによる相関解析2011

    • Author(s)
      前野信久, 加藤隆司, 藤原謙, 籏野健太郎, 田代学, 岡村信行, 谷内一彦, 伊藤健吾
    • Organizer
      第51回日本核医学会学術総会
    • Place of Presentation
      つくば国際会議場茨城県つくば市
    • Year and Date
      2011-10-29
  • [Presentation] 名古屋市総合リハビリテーションセンターにおけるPiB PiB-PET検査の現状2011

    • Author(s)
      田島稔久, 日比野新, 飯田昭彦, 加藤隆司, 伊藤健吾
    • Organizer
      第51回日本核医学会学術総会
    • Place of Presentation
      つくば国際会議場茨城県つくば市
    • Year and Date
      2011-10-29
  • [Presentation] SEAD-J study group, J-ADNI FDG-PET画像を用いたMCIからADへの移行予測: SEAD-JとUS-ADNIの比較2011

    • Author(s)
      藤原謙, 加藤隆司, 伊藤健吾
    • Organizer
      第51回日本核医学会学術総会
    • Place of Presentation
      つくば国際会議場茨城県つくば市
    • Year and Date
      2011-10-28
  • [Presentation] FDG PETの現況と展望, J-ADNIにおけるPET研究の進歩2011

    • Author(s)
      伊藤健吾, 藤原謙, 加藤隆司
    • Organizer
      第12回日本脳神経核医学研究会
    • Place of Presentation
      つくば国際会議場茨城県つくば市
    • Year and Date
      2011-10-27
  • [Presentation] J-ADNI study group. A newly proposed method to define cerebellar reference region optimized for individual BF-227 PET : Clinical validation in a multi-center study2011

    • Author(s)
      Fujiwara K, Kato T, Ito K, Hatano K, Okamura N, Yanai K, NCGG Memory Clinic
    • Organizer
      Alzheimer's Association International Conference 2011, Paris Porte de Versailles Convention and Exhibition Center
    • Place of Presentation
      Paris, Republic of France
    • Year and Date
      2011-07-20
  • [Presentation] Relationship between cerebral glucose metabolism and [C-11] BF-227 accumulation in the stages from cognitively normal to amnestic MCI2011

    • Author(s)
      Kato T, Ito K, Hatano K, Fujiwara K, Nakamura A, Washimi Y, Arahata Y, Hattori H, Miura H, Okamura N, Yanai K
    • Organizer
      Alzheimer's Association International Conference 2011, Paris Porte de Versailles Convention and Exhibition Center
    • Place of Presentation
      Paris, Republic of France
    • Year and Date
      2011-07-20
  • [Presentation] Spatial normalization using BF-227 template and MRI template : A comparative study2011

    • Author(s)
      Fujiwara K, Kato T, Ito K, Hatano K, Okamura N, Yanai K, NCGG Memory Clinic
    • Organizer
      58th Annual Meeting of the Society of Nuclear Medicine(SNM2011)
    • Place of Presentation
      San Antonio, Texas, USA
    • Year and Date
      2011-06-06
  • [Presentation] A newly proposed method to define cerebellar reference region optimized for individual BF-227 PET2011

    • Author(s)
      Fujiwara K, Kato T, Ito K, Hatano K, Okamura N, Yanai K, NCGG Memory Clinic
    • Organizer
      58th Annual Meeting of the Society of Nuclear Medicine(SNM2011)
    • Place of Presentation
      San Antonio, Texas, USA
    • Year and Date
      2011-06-06
  • [Presentation] NCGG Memory Clinic. An examination of relationship between brain atrophy with VBM-MR images and β-amyloid deposits with BF-227 PET images2011

    • Author(s)
      Maeno N, Kato T, Fujiwara K, Hatano K, Okamura N, Yanai K, Ito K
    • Organizer
      58th Annual Meeting of the Society of Nuclear Medicine(SNM2011)
    • Place of Presentation
      San Antonio, Texas, USA
    • Year and Date
      2011-06-06
  • [Presentation] Estimation of the conversion of mild cognitive impairment to Alzheimer's disease by AD t-sum method2011

    • Author(s)
      Yamada T, Kato T, Fujiwara K, Ito K
    • Organizer
      58th Annual Meeting of the Society of Nuclear Medicine(SNM2011)
    • Place of Presentation
      San Antonio, Texas, USA
    • Year and Date
      2011-06-06
  • [Presentation] SEAD-J Study Group. Prediction of conversion from amnestic MCI to Alzheimer's disease using principal component analysis of FDG PET2011

    • Author(s)
      Kato T, Ito K, Fujiwara K, Yamada T, Nakamura A
    • Organizer
      58th Annual Meeting of the Society of Nuclear Medicine(SNM2011)
    • Place of Presentation
      San Antonio, Texas, USA
    • Year and Date
      2011-06-06

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Published: 2013-07-31  

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