2010 Fiscal Year Final Research Report
The local gene transfer for prevention of thrombosis after percutaneous transluminal angioplasty.
| Project/Area Number |
20591481
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | University of Miyazaki |
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Principal Investigator |
TAMURA Syozo University of Miyazaki, 医学部, 教授 (60150439)
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| Co-Investigator(Kenkyū-buntansha) |
YANO Takanori 宮崎大学, 医学部, 講師 (20315378)
HATAKEYAMA Kinta 宮崎大学, 医学部, 講師 (60325735)
YAMASHITA Atushi 宮崎大学, 医学部, 助教 (90372797)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 血栓 / 遺伝子 / ADAMTS13 / 静脈 / 循環器・高血圧 |
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| Research Abstract |
Anticoagulation is the usual treatment for prevention of thrombosis after percutaneous transluminal angioplasty. But excessive or spontaneous bleeding may be a side effect of anticoagulation. The present study examines whether local gene transfer suppress platelet aggregation and thrombus formation after adenovirus-mediated gene transfer to injured arterial wall. Conclusion ; the local gene transfer to injured arterial wall might prevent thrombosis.
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