2010 Fiscal Year Final Research Report
Development of radiated immunotoxin anti-cancer drug and IL13-PE38QQR positron tracer
| Project/Area Number |
20591498
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Yokohama City University |
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Principal Investigator |
CHUMPOL Theeraladanon Yokohama City University, 医学研究科, 特任准教授 (20448682)
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| Co-Investigator(Kenkyū-buntansha) |
INOUE Tomio 横浜市立大学, 医学研究科, 教授 (80134295)
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| Project Period (FY) |
2008 – 2010
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| Keywords | IL-13受容体 / ポジトロン製剤 / 腫瘍イメージング / ^<90>Y標識 |
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| Research Abstract |
We performed the basic research in vitro and in vivo experiments with Y-90 labeled IL-13PE Cytotoxin after agreement of material transfer with FDA CBER, and using IL-13 PE Cytotoxin that had been offered from FDA CBER Dr. Puri. Y-90 labeled IL-13PE Cytotoxin is expected the both effect to target IL-13 receptors (IL-13R) for cancer therapy and cellular damage by β-emitter, so Y-90 labeled IL-13PE Cytotoxin is expected for the new radiation anti-cancer Imunotoxin treatment.
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