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2012 Fiscal Year Final Research Report

Targeting of anticancer drug, using radiosensitive microcapsules via radiotherapy.

Research Project

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Project/Area Number 20591503
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionIwate Medical University

Principal Investigator

HARADA Satoshi  岩手医科大学, 医学部, 講師 (20244931)

Co-Investigator(Kenkyū-buntansha) SERA Koichiro  岩手医科大学, 医学部, 教授 (00230855)
KAMIYA Tomihiro  独立行政法人日本原子力研究開発機構, 高崎量子応用研究所・ビーム技術開発課, ビーム技術開発室室長 (70370385)
Project Period (FY) 2008 – 2012
Keywords放射線治療生物学 / Drug delivery system
Research Abstract

We have developed microcapsules that release anticancer drug with response to radiation. Those microcapsules were injected around the experimental tumors in left hind legs of mice, then radiation was given to tumors. As a result, the antitumor effect was enhanced by synergistic effect between radiation and anticancer drugs, and adverse effect of anticancer drugs was decreased by localization of anticancer drugs by microcapsules.

  • Research Products

    (20 results)

All 2012 2011 2010 2009 2008

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (16 results)

  • [Journal Article] Decreasing size of radiosensitive capsules from micro to nano, and its increased antitumor effect and decreasing adverse effect2012

    • Author(s)
      S. Harada, S. Ehara, K. Ishii, H. Yamazaki, S. Matsuyama, T. Sato, T. Kamiya, K.sera and Y. Saito.
    • Journal Title

      Int.J. PIXE

      Volume: Vol 22 Pages: 57-64

    • Peer Reviewed
  • [Journal Article] Increa sing antitumor effects of chemoradiotherapy by drug efflux inhibition wit encapsulated RLIP -76. Int.2011

    • Author(s)
      S. Harada, S. Ehara, K. Ishii, A. Tanaka, T. Satoh, S. Matsuyama, H. Yamazaki, T. Kamiya, T. Sakai, K. Arakawa, M. Saitoh, S. Oikawa and K. Sera.
    • Journal Title

      Int.J. PIXE

      Volume: Vol 21 Pages: 30-36

    • Peer Reviewed
  • [Journal Article] Improved radiosensitive microcapsules using H2O2.2010

    • Author(s)
      S. Harada, S. Ehara, K. Ishii, A. Tanaka, T. Satoh, S. Matsuyama, H. Yamazaki, Y. Komori, T. Kamiya, T. Arakawa, M. Saitoh, M. Oikawa, and K. sera
    • Journal Title

      Improved radiosensitive microcapsules using H2O2.

      Volume: Vol 20 Pages: 30-36

    • Peer Reviewed
  • [Journal Article] Targeted Delivery of Chemotherapeutic Agents by using Improved Radiosensitive Liquid-Core Microcapsules and Assessment of Their Antitumor Effect.2009

    • Author(s)
      S. Harada, S. Ehara, K. Ishii, A. Tanaka, T. Satoh, S. Matsuyama, H. Yamazaki, Y. Komori, T. Kamiya, T. Arakawa, M. Saitoh, M. Oikawa, and K. sera
    • Journal Title

      Int. J. Radiation Oncology, Biol. Phys

      Volume: Vol 175 Pages: 455-462

    • Peer Reviewed
  • [Presentation] I Imaging of premetastatic sites and prophylaxis of metastasis using radiosensitive nanocapsules via radiotherapy.2012

    • Author(s)
      Satoshi Harada, Shigeru Ehara, Keizoh Ishii, Shigeo Matsuyama, Takuro Sakai, Yoshihiro Obara, Takahiro Sato , Masakazu Oikawa, Koichiro Sera
    • Organizer
      52th Annual meeting of American Society of Therapeutic Radiation Oncology
    • Place of Presentation
      Boston , USA.
    • Year and Date
      20121028-30
  • [Presentation] Decreasing size of radiosensitive nanocapsules from micro to nano, and its increased antitumor effect and decrea sing antitumor effect.2012

    • Author(s)
      Satoshi Harada, Shigeru Ehara, Keizoh Ishii, Hiromichi Yamazaki, Shigeo Matsuyama, Takuro Sakai, Yoshihiro Obara, Takahiro Sato, Masakazu Oikawa, Koichiro Sera
    • Organizer
      IJ PIXE
    • Year and Date
      20120000
  • [Presentation] Nanoparticle imaging of premetastatic sites and metastasis prophylaxis using radiation-induced release from liquid core nanocapsules2012

    • Author(s)
      Satoshi Harada, Shigeru Ehara, Keizoh Ishii, Hiromichi Yamazaki, Shigeo Matsuyama, Takuro Sakai, Yoshihiro Obara, Takahiro Sato, Masakazu Oikawa, Koichiro Sera
    • Organizer
      97th Annual Meeting of Radiological Society o f North America
    • Place of Presentation
      Chicago, IL USA
    • Year and Date
      2012-11-25
  • [Presentation] Imaging and treatment of incipient metastasis using radiosensitive nanocapsules via 2 radiotherapy sessions2011

    • Author(s)
      Satoshi Harada, Shigeru Ehara, Keizoh Ishii, Hiromichi Yamazaki, Shigeo Matsuyama, Takuro Sakai, Yoshihiro Obara, Takahiro Sato, Masakazu Oikawa, Koichiro Sera
    • Organizer
      511h Annual meeting of American Society of Therapeutic Radiation Oncology
    • Place of Presentation
      Miami FL , USA.
    • Year and Date
      20111002-04
  • [Presentation] Nanoparticle imaging of incipient metastasis and radiation-induced release of liquid-core nanocapsules for treatment of metastatic foci via O2 radiosensitization2011

    • Author(s)
      Satoshi Harada, Shigeru Ehara, Keizoh Ishii, Hiromichi Yamazaki, Shigeo Matsuyama, Takuro Sakai, Yoshihiro Obara, Takahiro Sato, Masakazu Oikawa, Koichiro Sera
    • Organizer
      96th Annual Meeting of Radiological Society of North America.
    • Place of Presentation
      Chicago, IL USA
    • Year and Date
      2011-11-28
  • [Presentation] Decreasing size of radiosensitive capsules from micro to nano, and its increased antitumor effect and decreasing adverse effect2011

    • Author(s)
      Satoshi Harada, Shigeru Ehara, Ke izoh Ishii, Hiromichi Yamazaki, Shigeo Matsuyama, Takuro Sakai, Yoshihiro Obara, Takahiro Sato, Masakazu Oikawa,Koichiro Sera
    • Organizer
      International Conference of BIO-PIXE 7.
    • Place of Presentation
      Sendai Japan .
    • Year and Date
      2011-10-31
  • [Presentation] Targeting of anticancer drugs using liquid core microcapsules via radiotherapy.2011

    • Author(s)
      Satoshi Harada, Shigeru Ehara, Keizoh Ishii, Hiromichi Yamazaki, Shigeo Matsuyama, Takuro Sakai, Yoshihiro Obara, Takahiro Sato, Masakazu Oikawa, Koichiro Sera
    • Organizer
      2nd World Congress on Bioavailability & Bioequivalence: Pharmaceutical R & D Summit
    • Place of Presentation
      Las Vegas NV USA .
    • Year and Date
      2011-06-07
  • [Presentation] Inhibition of metastasis and enhancement of antitumor effect usin liquid core nanocapsules via radiotherapy.2010

    • Author(s)
      Satoshi Harada, Shigeru Ehara, Keizoh Ishii, Hiromichi Yamazaki, Shigeo Matsuyama, Takuro Sakai, Yoshihiro Obara, Takahiro Sato, Masakazu Oikawa, Koichiro Sera
    • Organizer
      511h Annual meeting of American Society of Therapeutic Radiation Oncology
    • Place of Presentation
      San Diego CA, USA .
    • Year and Date
      20101102-03
  • [Presentation] Nanoparticle imaging of the metastatic potential of tumor cells and irradiation -induced release of liquid-core nanocapsules for inhibition of metastasis and O2 radiosensitization2010

    • Author(s)
      Satoshi Harada, Shigeru Ehara, Keizoh Ishii, Hiromichi Yamazaki, Shigeo Matsuyama, Takuro Sakai, Yoshihiro Obara, Takahiro Sato, Masakazu Oikawa, Koichiro Sera
    • Organizer
      95th Annual Meeting of Radiological Society of North America.
    • Place of Presentation
      Chicago, IL USA
    • Year and Date
      2010-11-28
  • [Presentation] Inhibition Of Metastasis By Using Radiation-Sensitive Microcapsules2010

    • Author(s)
      H Satoshi Harada, Shigeru Ehara, Keizoh Ishii, Hiromichi Yamazaki, Shigeo Matsuyama, Takuro Sakai, Yoshihiro Obara, Takahiro Sato , Masakazu Oikawa, Koichiro Sera
    • Organizer
      12th International Conference on Particle Induced X-ray Emission and it is Analytical Applications.
    • Place of Presentation
      Guildford UK
    • Year and Date
      2010-07-01
  • [Presentation] Radiosensitization by oxygen effect under normal breathing, inhibition of invasion and metastasis, using liquid core microcapsules accumulated through radiation.2009

    • Author(s)
      Satoshi Harada, Shigeru Ehara, Keizoh Ishii, Hiromichi Yamazaki, Shigeo Matsuyama, Takuro Sakai, Yoshihiro Obara, Takahiro Sato, Masakazu Oikawa, Koichiro Sera
    • Organizer
      94th Annual Meeting of Radiological Society of North America.
    • Place of Presentation
      Chicago, IL USA
    • Year and Date
      2009-11-28
  • [Presentation] Inhibition of metastasis and enhancement of antitumor effect usin liquid core nanocapsules via radiotherapy.2009

    • Author(s)
      Satoshi Harada, Shigeru Ehara, Keizoh Ishii, Hiromichi Yamazaki, Shigeo Matsuyama, Takuro Sakai, Yoshihiro Obara, Takahiro Sato, Masakazu Oikawa, Koichiro Sera
    • Organizer
      501h Annual meeting of American Society of Therapeutic Radiation Oncology
    • Place of Presentation
      Chicago IL USA .
    • Year and Date
      2009-11-04
  • [Presentation] The use of fluoroscopically detectable, tumor-infiltrating microcapsules enables multidrug targeting and endocytosis via radiotherapy.2008

    • Author(s)
      Satoshi Harada, Shigeru Ehara, Keizoh Ishii, Shigeo Matsuyama, Takuro Sakai, Yoshihiro Obara, Takahiro Sato , Masakazu Oikawa, Koichiro Sera
    • Organizer
      50th Annual meeting of American Society of Therapeutic Radiation Oncology
    • Place of Presentation
      Boston MA USA.
    • Year and Date
      20080921-25
  • [Presentation] Masakazu Oikawa, Koichiro Sera , Radiosensitization via oxygen effect by using microcapsules with a highly oxygenated liquid core that is released on irradiation2008

    • Author(s)
      Satoshi Harada, Shigeru Ehara, Keizoh Ishii, Hiromichi Yamazaki, Shigeo Matsuyama, Takuro Sakai, Yoshihiro Obara, Takahiro Sato, Masakazu Oikawa, Koichiro Sera
    • Organizer
      94th Annual Meeting of Radiological Society of North America.
    • Place of Presentation
      Chicago, IL USA
    • Year and Date
      2008-11-30
  • [Presentation] Innovation of microcapsules that enables drug targeting through radiotherapy2008

    • Author(s)
      Satoshi Harada, Shigeru Ehara, Keizoh Ishii, Hiromichi Yamazaki, Shigeo Matsuyama, Takuro Sakai, Yoshihiro Obara, Takahiro Sato, Masakazu Oikawa, Koichiro Sera, Innovation of microcapsules tha
    • Organizer
      CAARI 2008
    • Place of Presentation
      Dallas TX USA.
    • Year and Date
      2008-08-10
  • [Presentation] MEDICAL APPLICATION OF PARTICLE INDUCED X-RAY EMISSION.2008

    • Author(s)
      Harada, Satoshi ; Ehara, Shigeru ; Ishii, Keizoh ; Yamazaki, Hiromichi ; Matsuyama, Shigeo ; Sakai, Takuro ; Obara, Yoshihiro ; Sato, Takahiro ; Oikawa, Masakazu ; Sera, Koichiro
    • Organizer
      International Symposium of Bio PIXE 6.
    • Place of Presentation
      Richland, WA USA
    • Year and Date
      2008-06-20

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Published: 2014-08-29  

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