Targeting of anticancer drug, using radiosensitive microcapsules via radiotherapy.

2012 Fiscal Year Final Research Report

• Project/Area Number: 20591503
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Iwate Medical University
• Principal Investigator: HARADA Satoshi 岩手医科大学, 医学部, 講師 (20244931)
• Co-Investigator(Kenkyū-buntansha): SERA Koichiro 岩手医科大学, 医学部, 教授 (00230855) ; KAMIYA Tomihiro 独立行政法人日本原子力研究開発機構, 高崎量子応用研究所・ビーム技術開発課, ビーム技術開発室室長 (70370385)
• Project Period (FY): 2008 – 2012
• Keywords: 放射線治療生物学 / Drug delivery system

Research Abstract

We have developed microcapsules that release anticancer drug with response to radiation. Those microcapsules were injected around the experimental tumors in left hind legs of mice, then radiation was given to tumors. As a result, the antitumor effect was enhanced by synergistic effect between radiation and anticancer drugs, and adverse effect of anticancer drugs was decreased by localization of anticancer drugs by microcapsules.

Research Products

• [Journal Article] Decreasing size of radiosensitive capsules from micro to nano, and its increased antitumor effect and decreasing adverse effect (2012)
  • Author(s): S. Harada, S. Ehara, K. Ishii, H. Yamazaki, S. Matsuyama, T. Sato, T. Kamiya, K.sera and Y. Saito.
  • Journal Title: Int.J. PIXE Volume: Vol 22 Pages: 57-64
  • Peer Reviewed
• [Journal Article] Increa sing antitumor effects of chemoradiotherapy by drug efflux inhibition wit encapsulated RLIP -76. Int. (2011)
  • Author(s): S. Harada, S. Ehara, K. Ishii, A. Tanaka, T. Satoh, S. Matsuyama, H. Yamazaki, T. Kamiya, T. Sakai, K. Arakawa, M. Saitoh, S. Oikawa and K. Sera.
  • Journal Title: Int.J. PIXE Volume: Vol 21 Pages: 30-36
  • Peer Reviewed
• [Journal Article] Improved radiosensitive microcapsules using H2O2. (2010)
  • Author(s): S. Harada, S. Ehara, K. Ishii, A. Tanaka, T. Satoh, S. Matsuyama, H. Yamazaki, Y. Komori, T. Kamiya, T. Arakawa, M. Saitoh, M. Oikawa, and K. sera
  • Journal Title: Improved radiosensitive microcapsules using H2O2. Volume: Vol 20 Pages: 30-36
  • Peer Reviewed
• [Journal Article] Targeted Delivery of Chemotherapeutic Agents by using Improved Radiosensitive Liquid-Core Microcapsules and Assessment of Their Antitumor Effect. (2009)
  • Author(s): S. Harada, S. Ehara, K. Ishii, A. Tanaka, T. Satoh, S. Matsuyama, H. Yamazaki, Y. Komori, T. Kamiya, T. Arakawa, M. Saitoh, M. Oikawa, and K. sera
  • Journal Title: Int. J. Radiation Oncology, Biol. Phys Volume: Vol 175 Pages: 455-462
  • Peer Reviewed
• [Presentation] I Imaging of premetastatic sites and prophylaxis of metastasis using radiosensitive nanocapsules via radiotherapy. (2012)
  • Author(s): Satoshi Harada, Shigeru Ehara, Keizoh Ishii, Shigeo Matsuyama, Takuro Sakai, Yoshihiro Obara, Takahiro Sato , Masakazu Oikawa, Koichiro Sera
  • Organizer: 52th Annual meeting of American Society of Therapeutic Radiation Oncology
  • Place of Presentation: Boston , USA.
  • Year and Date: 20121028-30
• [Presentation] Decreasing size of radiosensitive nanocapsules from micro to nano, and its increased antitumor effect and decrea sing antitumor effect. (2012)
  • Author(s): Satoshi Harada, Shigeru Ehara, Keizoh Ishii, Hiromichi Yamazaki, Shigeo Matsuyama, Takuro Sakai, Yoshihiro Obara, Takahiro Sato, Masakazu Oikawa, Koichiro Sera
  • Organizer: IJ PIXE
  • Year and Date: 20120000
• [Presentation] Nanoparticle imaging of premetastatic sites and metastasis prophylaxis using radiation-induced release from liquid core nanocapsules (2012)
  • Author(s): Satoshi Harada, Shigeru Ehara, Keizoh Ishii, Hiromichi Yamazaki, Shigeo Matsuyama, Takuro Sakai, Yoshihiro Obara, Takahiro Sato, Masakazu Oikawa, Koichiro Sera
  • Organizer: 97th Annual Meeting of Radiological Society o f North America
  • Place of Presentation: Chicago, IL USA
  • Year and Date: 2012-11-25
• [Presentation] Imaging and treatment of incipient metastasis using radiosensitive nanocapsules via 2 radiotherapy sessions (2011)
  • Author(s): Satoshi Harada, Shigeru Ehara, Keizoh Ishii, Hiromichi Yamazaki, Shigeo Matsuyama, Takuro Sakai, Yoshihiro Obara, Takahiro Sato, Masakazu Oikawa, Koichiro Sera
  • Organizer: 511h Annual meeting of American Society of Therapeutic Radiation Oncology
  • Place of Presentation: Miami FL , USA.
  • Year and Date: 20111002-04
• [Presentation] Nanoparticle imaging of incipient metastasis and radiation-induced release of liquid-core nanocapsules for treatment of metastatic foci via O2 radiosensitization (2011)
  • Author(s): Satoshi Harada, Shigeru Ehara, Keizoh Ishii, Hiromichi Yamazaki, Shigeo Matsuyama, Takuro Sakai, Yoshihiro Obara, Takahiro Sato, Masakazu Oikawa, Koichiro Sera
  • Organizer: 96th Annual Meeting of Radiological Society of North America.
  • Place of Presentation: Chicago, IL USA
  • Year and Date: 2011-11-28
• [Presentation] Decreasing size of radiosensitive capsules from micro to nano, and its increased antitumor effect and decreasing adverse effect (2011)
  • Author(s): Satoshi Harada, Shigeru Ehara, Ke izoh Ishii, Hiromichi Yamazaki, Shigeo Matsuyama, Takuro Sakai, Yoshihiro Obara, Takahiro Sato, Masakazu Oikawa,Koichiro Sera
  • Organizer: International Conference of BIO-PIXE 7.
  • Place of Presentation: Sendai Japan .
  • Year and Date: 2011-10-31
• [Presentation] Targeting of anticancer drugs using liquid core microcapsules via radiotherapy. (2011)
  • Author(s): Satoshi Harada, Shigeru Ehara, Keizoh Ishii, Hiromichi Yamazaki, Shigeo Matsuyama, Takuro Sakai, Yoshihiro Obara, Takahiro Sato, Masakazu Oikawa, Koichiro Sera
  • Organizer: 2nd World Congress on Bioavailability & Bioequivalence: Pharmaceutical R & D Summit
  • Place of Presentation: Las Vegas NV USA .
  • Year and Date: 2011-06-07
• [Presentation] Inhibition of metastasis and enhancement of antitumor effect usin liquid core nanocapsules via radiotherapy. (2010)
  • Author(s): Satoshi Harada, Shigeru Ehara, Keizoh Ishii, Hiromichi Yamazaki, Shigeo Matsuyama, Takuro Sakai, Yoshihiro Obara, Takahiro Sato, Masakazu Oikawa, Koichiro Sera
  • Organizer: 511h Annual meeting of American Society of Therapeutic Radiation Oncology
  • Place of Presentation: San Diego CA, USA .
  • Year and Date: 20101102-03
• [Presentation] Nanoparticle imaging of the metastatic potential of tumor cells and irradiation -induced release of liquid-core nanocapsules for inhibition of metastasis and O2 radiosensitization (2010)
  • Author(s): Satoshi Harada, Shigeru Ehara, Keizoh Ishii, Hiromichi Yamazaki, Shigeo Matsuyama, Takuro Sakai, Yoshihiro Obara, Takahiro Sato, Masakazu Oikawa, Koichiro Sera
  • Organizer: 95th Annual Meeting of Radiological Society of North America.
  • Place of Presentation: Chicago, IL USA
  • Year and Date: 2010-11-28
• [Presentation] Inhibition Of Metastasis By Using Radiation-Sensitive Microcapsules (2010)
  • Author(s): H Satoshi Harada, Shigeru Ehara, Keizoh Ishii, Hiromichi Yamazaki, Shigeo Matsuyama, Takuro Sakai, Yoshihiro Obara, Takahiro Sato , Masakazu Oikawa, Koichiro Sera
  • Organizer: 12th International Conference on Particle Induced X-ray Emission and it is Analytical Applications.
  • Place of Presentation: Guildford UK
  • Year and Date: 2010-07-01
• [Presentation] Radiosensitization by oxygen effect under normal breathing, inhibition of invasion and metastasis, using liquid core microcapsules accumulated through radiation. (2009)
  • Author(s): Satoshi Harada, Shigeru Ehara, Keizoh Ishii, Hiromichi Yamazaki, Shigeo Matsuyama, Takuro Sakai, Yoshihiro Obara, Takahiro Sato, Masakazu Oikawa, Koichiro Sera
  • Organizer: 94th Annual Meeting of Radiological Society of North America.
  • Place of Presentation: Chicago, IL USA
  • Year and Date: 2009-11-28
• [Presentation] Inhibition of metastasis and enhancement of antitumor effect usin liquid core nanocapsules via radiotherapy. (2009)
  • Author(s): Satoshi Harada, Shigeru Ehara, Keizoh Ishii, Hiromichi Yamazaki, Shigeo Matsuyama, Takuro Sakai, Yoshihiro Obara, Takahiro Sato, Masakazu Oikawa, Koichiro Sera
  • Organizer: 501h Annual meeting of American Society of Therapeutic Radiation Oncology
  • Place of Presentation: Chicago IL USA .
  • Year and Date: 2009-11-04
• [Presentation] The use of fluoroscopically detectable, tumor-infiltrating microcapsules enables multidrug targeting and endocytosis via radiotherapy. (2008)
  • Author(s): Satoshi Harada, Shigeru Ehara, Keizoh Ishii, Shigeo Matsuyama, Takuro Sakai, Yoshihiro Obara, Takahiro Sato , Masakazu Oikawa, Koichiro Sera
  • Organizer: 50th Annual meeting of American Society of Therapeutic Radiation Oncology
  • Place of Presentation: Boston MA USA.
  • Year and Date: 20080921-25
• [Presentation] Masakazu Oikawa, Koichiro Sera , Radiosensitization via oxygen effect by using microcapsules with a highly oxygenated liquid core that is released on irradiation (2008)
  • Author(s): Satoshi Harada, Shigeru Ehara, Keizoh Ishii, Hiromichi Yamazaki, Shigeo Matsuyama, Takuro Sakai, Yoshihiro Obara, Takahiro Sato, Masakazu Oikawa, Koichiro Sera
  • Organizer: 94th Annual Meeting of Radiological Society of North America.
  • Place of Presentation: Chicago, IL USA
  • Year and Date: 2008-11-30
• [Presentation] Innovation of microcapsules that enables drug targeting through radiotherapy (2008)
  • Author(s): Satoshi Harada, Shigeru Ehara, Keizoh Ishii, Hiromichi Yamazaki, Shigeo Matsuyama, Takuro Sakai, Yoshihiro Obara, Takahiro Sato, Masakazu Oikawa, Koichiro Sera, Innovation of microcapsules tha
  • Organizer: CAARI 2008
  • Place of Presentation: Dallas TX USA.
  • Year and Date: 2008-08-10
• [Presentation] MEDICAL APPLICATION OF PARTICLE INDUCED X-RAY EMISSION. (2008)
  • Author(s): Harada, Satoshi ; Ehara, Shigeru ; Ishii, Keizoh ; Yamazaki, Hiromichi ; Matsuyama, Shigeo ; Sakai, Takuro ; Obara, Yoshihiro ; Sato, Takahiro ; Oikawa, Masakazu ; Sera, Koichiro
  • Organizer: International Symposium of Bio PIXE 6.
  • Place of Presentation: Richland, WA USA
  • Year and Date: 2008-06-20