2010 Fiscal Year Final Research Report
Gamma-ray-inducted regulatory T cells and attenuation of autoimmune diseases
| Project/Area Number |
20591506
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
KOJIMA Shuji Tokyo University of Science, 薬学部, 教授 (90119579)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 自己免疫疾患 / 小線量放射線 / 制御性T細胞 / 改善 |
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| Research Abstract |
Whole-body small doses of gamma-ray irradiation suppressed the productivity of pro-inflammatory cytokines and autoantibody, and the ratio of cytotoxic T cells in a few animal models, indicating that attenuation of autoimmune diseases. While, the ratio of Treg cells was significantly induced in all models, suggesting involvement of regulatory T cells in the attenuation by the irradiation. Recently, gene therapy of transcription of Treg gene against autoimmune diseases has been greatly noticed. The radiation therapy with a small-dose could be considered to be one of the promising ways for incurable autoimmune diseases in a near future.
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