2010 Fiscal Year Final Research Report
A study of the relationship between radiation-induced apoptosis and development of atherosclerosis.
| Project/Area Number |
20591507
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | National Institute of Radiological Sciences |
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Principal Investigator |
NAKAJIMA Tetsuo National Institute of Radiological Sciences, 放射線防護研究センター, 主任研究員 (80237271)
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| Project Period (FY) |
2008 – 2010
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| Keywords | シグナル伝達 / 放射線 / ストレス |
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| Research Abstract |
There is a concern that radiation induces atherosclerosis as side effects after radiotherapies. Radiation-induced apoptosis in vascular smooth muscle cells is one of possible mediating processes, because development of atherosclerosis is mediated by oxidative stresses, which can be apoptosis inducers. Radiation-induced apoptosis in the cells was evaluated under the presence of some mediators related to atherosclerosis. Radiation-induced apoptosis of vascular smooth muscle cells was increased by pre-treatment with oxLDL (oxidized low-density lipoproteins). It was also demonstrated that the process by oxLDL mediation involves protein kinase C and lipid peroxides.
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