2010 Fiscal Year Final Research Report
Restoration of self liver using transplantation of autologous cryopreserved hepatocytes.
| Project/Area Number |
20591529
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Nagasaki University |
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Principal Investigator |
EGUCHI Susumu Nagasaki University, 大学院・医歯薬学総合研究科, 准教授 (80404218)
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| Co-Investigator(Kenkyū-buntansha) |
KANEMATSU Takashi 長崎大学, 大学院・医歯薬学総合研究科, 教授 (40128004)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 肝細胞 / 幹細胞 / 自己再生型 |
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| Research Abstract |
This year we isolated human hepatocytes from resected liver specimen from patients with metastatic liver cancer. After some modification of the method of isolation, we could obtain intact human hepatocytes for transplantation. We transplanted those hepatocytes in nude mice and SCID mice.In addition, we used our original method to proliferate transplanted hepatocyte using radiation on host liver. Using those technique, after growth advantage, transplated human hepatocytes proliferate very well until replace a host liver to 95% By the time of 16 weeks. Around transplanted human hepatocytes, gap junction and glycogenesis were observed. Although auto transplantation has not been performed, concept of hepatocyte banking and retransplantation could be a good therapeutic choice for end stage liver diseases.
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[Journal Article] Macrophage-dominant sialadenitis inhuman T-cell leukemia virus type I-associated yelopathy after living-donor liver transplantation.2010
Author(s)
Nakamura H, Ichikawa T, Nakamura T, Kawakami A, Iwamoto N, Matsuzaki T, Miyaaki H, Yamasaki S, Ida H, Eguchi S,Hayashi T, Nakao K, Kanematsu T, Eguchi K.
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Journal Title
Transplantation Proceedings. 42
Pages: 2797-2799
Peer Reviewed
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[Remarks] ホームページ等
