2011 Fiscal Year Final Research Report
Introduction of humanβ-defensin-3 and human cathelicidine antimicrobial peptide-18 into cultured human skin cells
| Project/Area Number |
20591534
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Tokai University |
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Principal Investigator |
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| Research Collaborator |
ANDO Kiyoshi 東海大学, 医学部, 教授 (70176014)
UMEZAWA Kazuo 東海大学, 医学部, 講師 (30349344)
SUZUKI Yousuke 東海大学, 医学部, 講師 (90459454)
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| Project Period (FY) |
2008 – 2011
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| Keywords | 移植・再生医療 / 培養皮膚 / 抗菌ペプチド / ウイルスベクター / LL37 / hBD3 |
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| Research Abstract |
Humanβ-defensin-3(hBD3) gene and human cathelicidine antimicrobial peptide-18(hCAP18/LL37) gene were introduced into cultured human skin cells simultaneously by a recombinant adenovirus vector. The virus infected cells secreted both hBD3 and hCAP18, a pro-peptide of LL37.
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[Journal Article] Introduction of humanβ-defensin-3 into cultured human keratinocytes and fibroblasts by infection of a recombinant adenovirus vector2011
Author(s)
Suzuki Y, Inokuchi S, Takazawa K, Umezawa K, Saito T, Kidokoro M, Tanaka M, Matsuzawa H, Inoue S, Tsuchiya I, Ando K
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Journal Title
Burns
Volume: 37(1)
Pages: 109-16
Peer Reviewed
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