The role of the adipocyte function in the gender-specific medicine after the surgical stress : the effectiveness of the pioglitazone administration

2010 Fiscal Year Final Research Report

• Project/Area Number: 20591537
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General surgery
• Research Institution: Nippon Medical School
• Principal Investigator: MATSUTANI Takeshi Nippon Medical School, 医学部, 助教 (50366712)
• Co-Investigator(Kenkyū-buntansha): SASAJIMA Koji 日本医科大学, 医学部, 教授 (80158930) ; MATSUDA Akihisa 日本医科大学, 医学部, 助教 (00366741)
• Project Period (FY): 2008 – 2010
• Keywords: 外科総論 / 手術侵襲 / 性差医療 / 脂肪細胞 / ピオグリタゾン

Research Abstract

Adipose tissue is considered to be an endocrine/immune organ secreting a variety of biologically active molecules, conceptualized as adipokines. However, the mechanism of gender-related alterations in the innate function of adipose tissue after major surgery is still unknown. The aim of this study was to investigate the effect of gender differences in innate inflammatory responses and the function of adipose tissue in patients undergoing major gastrointestinal gastrointestinal surgery. There were no significant differences in terms of age, operation time, or blood loss between male and female patients. However, the women had a significantly lower morbidity rate due to postoperative complication than did the men. Preoperative levels of adiponectin and leptin were lower in male patients than in female patients and postoperative adiponectin and leptin levels have clearly shown lower inflammatory responses in women after surgery. These findings suggest that male patients might develop postoperative immune suppression after major surgery, whereas female patients have an immunological advantage including adipose function during the early postoperative period.

Research Products

• [Journal Article] Preoperative plasma adiponectin level is a risk factor for postoperative infection following colorectal cancer surgery. (2009)
  • Author(s): A.Matsuda, T.Matsutani, K.Sasajima, K Furukawa, T Tajiri, K Tamura, H Kogo
  • Journal Title: J Surg Res 157 Pages: 227-234
  • Peer Reviewed
• [Journal Article] Increases in soluble tumor necrosis factor receptors coincide with increases in interleukin-6 and proteinases after major surgery. (2009)
  • Author(s): K.Sasajima, R Futami, T.Matsutani, T Nomura, H Makino, H Maruyama, M Miyashita
  • Journal Title: Hepatogastroenterology 56 Pages: 1377-1381
  • Peer Reviewed
• [Journal Article] 脂肪細胞からみた手術侵襲後の生体防御反応と術後感染症 (2008)
  • Author(s): 松田明久,松谷毅,笹島耕二,丸山弘,宮本昌之,横山正,鈴木成治,田村和広,向後博司,古川清憲,田尻孝
  • Journal Title: 成人病と生活習慣病 38 Pages: 521-524
• [Journal Article] 脂肪細胞機能からみた術後感染症発症予測とは? (2008)
  • Author(s): 松田明久,松谷毅,笹島耕二,丸山弘,宮本昌之,横山正,鈴木成治,田村和広,古川清憲,田尻孝
  • Journal Title: 悲観と糖尿病 8 Pages: 339-341
• [Journal Article] Gender-related differences in circulating levels of adipocytokine associated with postoperative complication following major surgery. (2008)
  • Author(s): T.Matsutani, A.Matsuda, K.Sasajima, T Tajiri
  • Journal Title: J Nippon Med Sch 76 Pages: 50-52
• [Journal Article] Prevention of postoperative infection and micrometastasis by preoperative administration of a PPAR-g agonist following colorectal cancer surgery. (2008)
  • Author(s): A.Matsuda, K.Sasajima, T.Matsutani, T Tajiri
  • Journal Title: J Nippon Med Sch 76 Pages: 47-49
• [Presentation] A role of PPAR-gamma in salutary effects on omental adipocyte functions following polymicrobial sepsis. (2010)
  • Author(s): Matsutani T, Matsuda A, Yoshida H, Miyashita M, Uchida E, , Tsujimura Y, Kutsukake M, Tamura K, Sasajima K
  • Organizer: 33nd annual conference on Shock
  • Place of Presentation: Portland, USA
  • Year and Date: 20100600
• [Presentation] 術前PPAR-γリガンド投与による抗炎症作用-マウス腹膜炎モデルにおける脂肪細胞機能に着目して- (2010)
  • Author(s): 松谷毅,内田英二,松田明久,丸山弘,鈴木成治,横山正,杉浦篤,松下晃,新井洋紀,笹島耕二
  • Organizer: 第110回日本外科学会定期学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 20100400
• [Presentation] Gender-related differences in circulating levels of adipocytokine associated with postoperative complication following thoracic-abdominal surgery. (2009)
  • Author(s): Matsutani T, Matsuda A, Sasajima K, Miyashita M, Tajiri T, Tsujimura Y, Tamura K, Chaudry IH
  • Organizer: 32nd annual conference on Shock
  • Place of Presentation: San Antonio, USA
  • Year and Date: 20090600
• [Presentation] PPARg attenuates inflammatory response through the activation of adipocyte in mice polymicrobial sepsis. (2009)
  • Author(s): Matsuda A, Matsutani T, Sasajima K, Miyashita M, Tajiri T, Tsujimura Y, Tamura K
  • Organizer: 32nd annual conference on Shock
  • Place of Presentation: San Antonio, USA
  • Year and Date: 20090600
• [Presentation] マウス敗血症モデルにおけるPPAR-γアゴニストの抗炎症作用-脂肪細胞機能に着目して- (2009)
  • Author(s): 松田明久,松谷毅,笹島耕二,丸山弘,古川清憲,辻村行啓,田村和広,田尻孝,内田英二
  • Organizer: 第24回日本ショック学会総会
  • Place of Presentation: 金沢
  • Year and Date: 20090500
• [Presentation] 食道癌手術における術後合併症とgender difference-脂肪細胞機能に着目して- (2009)
  • Author(s): 松谷毅,笹島耕二,松田明久,丸山弘,鈴木成治,松下晃,宮下正夫,田尻孝,内田英二,辻村行啓,田村和広
  • Organizer: 第24回日本ショック学会総会
  • Place of Presentation: 金沢
  • Year and Date: 20090500
• [Presentation] 性差からみた食道癌手術後の生体防御反応と術前ステロイド投与の影響 (2008)
  • Author(s): 松谷毅,笹島耕二,松田明久,鈴木成治,丸山弘,宮本昌之,横山正,柳健,松下晃,柏原元,宮下正夫,田尻孝
  • Organizer: 第50回日本消化器病学会総会
  • Place of Presentation: 東京
  • Year and Date: 20081000
• [Presentation] 男性患者における手術侵襲後の合併症とアディポカイン・性ホルモンの関連 (2008)
  • Author(s): 松谷毅,笹島耕二,松田明久,丸山弘,宮本昌之,横山正,鈴木成治,柳健,宮下正夫,田尻孝
  • Organizer: 第63回日本消化器外科学会総会
  • Place of Presentation: 札幌
  • Year and Date: 20080700
• [Presentation] 肥満関連mediatorとSSI発症との関連 (2008)
  • Author(s): 松田明久,松谷毅,笹島耕二,丸山弘,宮本昌之,横山正,鈴木成治,宮下正夫,古川清憲,田尻孝
  • Organizer: 第63回日本消化器外科学会総会
  • Place of Presentation: 札幌
  • Year and Date: 20080700
• [Presentation] Gender-related differences in immune responses following major surgical trauma are diminished by preoperative steroid administration. (2008)
  • Author(s): Matsutani T, Matsuda A, Sasajima K, Miyashita M, Tajiri T, Tamura K, Kogo H, Chaudry IH
  • Organizer: Shock congress 2008
  • Place of Presentation: Cologne, Germany
  • Year and Date: 20080600
• [Presentation] Depressed adipocyte function is a risk factor for postoperative infection following colorectal cancer surgery. (2008)
  • Author(s): Matsuda A, Matsutani T, Sasajima K, Furukawa K, Miyashita M, Tajiri T, Tamura K, Kogo H
  • Organizer: Shock congress 2008
  • Place of Presentation: Cologne, Germany
  • Year and Date: 20080600
• [Presentation] 脂肪細胞機能と大腸癌術後感染性合併症 (2008)
  • Author(s): 松田明久,松谷毅,笹島耕二,丸山弘,宮本昌之,横山正,鈴木成治,柳健,松下晃,宮下正夫,古川清憲,田尻孝
  • Organizer: 第23回日本Shock学会総会
  • Place of Presentation: 東京
  • Year and Date: 20080500
• [Presentation] 脂肪細胞機能低下は術後感染症発症の独立した危険因子である (2008)
  • Author(s): 松田明久,松谷毅,笹島耕二,丸山弘,宮本昌之,水谷崇,横山正,鈴木成治,柳健,松下晃,柏原元,古川清憲,鈴木英之,田尻孝
  • Organizer: 第108回日本外科学会定期学術集会
  • Place of Presentation: 長崎
  • Year and Date: 20080500
• [Presentation] 食道癌手術後の末梢血アディポカインとテストステロン値の関連 (2008)
  • Author(s): 松谷毅,笹島耕二,松田明久,丸山弘,宮本昌之,横山正,鈴木成治,柳健,柏原元,宮下正夫,田尻孝
  • Organizer: 第108回日本外科学会定期学術集会
  • Place of Presentation: 長崎
  • Year and Date: 20080500