2010 Fiscal Year Final Research Report
The development of novel cancer vaccine therapy using extracorporeal circulation system with immunosuppressive substance absorption column
| Project/Area Number |
20591552
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
ITOH Tsuyoshi Kyoto Prefectural University of Medicine, 医学研究科, 助教 (40420707)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 実験外科学 / 外科腫瘍学 / 腫瘍免疫学 |
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| Research Abstract |
In vitro experiments focusing on the immunological effects using lymphocytes derived from cancer bearing patients suggested that immunosuppressive factors increased inthose patients limited the therapeutic effects of cancer vaccine therapy. We developedhybrid column consisted of immunosuppressive substance absorptive column covered with lipoteicoic acids for immunotherapy of cancer. Lymphocytes induced byhemoperfusion treatment using immunosuppressive substance absorption (ISA) column hold enhanced activity in humoral and cellular immunity. This column has been proven to hold immunostimulative activities determined by mixed lymphocyte reaction (MLR) and PHA test. Cancer vaccine effects in vitro as well as in vivo were also demonstrated in experiments using tumor bearing rats. Furthermore, in vivo anti-tumor effect induced by ISA column was also suggested.
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Research Products
(18 results)
