Paclitaxel combined with hyarulonic acid as the new drug for peritoneal dissemination of gastric cancer.

2010 Fiscal Year Final Research Report

• Project/Area Number: 20591563
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: The University of Tokyo
• Principal Investigator: KITAYAMA Joji The University of Tokyo, 医学部附属病院, 准教授 (20251308)
• Co-Investigator(Kenkyū-buntansha): ISHIGAMI Hironori 東京大学, 医学部附属病院, 講師 (80372382)
• Co-Investigator(Renkei-kenkyūsha): HIDEMURA Akio 東京大学, 医学部附属病院, 助教 (70401099)
• Project Period (FY): 2008 – 2010
• Keywords: 腹膜播種 / 腹腔内化学療法 / パクリタキセル / シスプラチン / NASHA

Research Abstract

Intraperitoneal chemotherapy has been shown to be clinically useful for peritoneal matastais. In this study, we hypothesized that high molecular weight Hyarulonic Acid may retain the intraperitoneally administrated anticancer drugs in abdominal cavity and enhance the anti-tumor effects, and examined the effect of Non-Animal Stabilized Hyarulonic Acid (NASHA) (Q-Med Sweden). In fact, the addition of 5% NASHA suppressed the development of peritoneal nodules of MKN45 inplanted in nude mice significantly greater than paclitaxel or cisplatin alone. NASHA also increased the volume of fluid recovered from the mice. Intraperitoneal administration paclitaxel or cisplatin combined with NASHA can be a hopeful strategy as the treatment of peritoneal dissemination.

Research Products

• [Journal Article] Spatial Distribution of Intraperitoneally Administrated Paclitaxel Nanoparticles Solubilized with Poly (2-methacryloxyethyl phosphorylcholine-co n-butyl methacrylate) in Peritoneal Metastatic Nodules. (2011)
  • Author(s): Kamei T, Kitayama J, Yamaguchi H, Soma D, Emoto S, Konno T, Ishihara K, Ishigami H, Kaisaki S, Nagawa H
  • Journal Title: Cancer Sci 102(1) Pages: 200-205
  • Peer Reviewed
• [Journal Article] Weekly intravenous and intraperitoneal paclitaxel combined with S-1 for malignant ascites due to advanced gastric cancer. (2010)
  • Author(s): Kitayama J, Ishigami H, Kaisaki S, Hidemura A, Kato M, Otani K, Kamei T, Soma D, Miyato H, Yamashita H, Nagawa H
  • Journal Title: Oncology. 78(1) Pages: 40-6
  • Peer Reviewed
• [Journal Article] 胃癌腹膜播種の治療戦略 (2010)
  • Author(s): 石神浩徳,北山丈二,名川弘一
  • Journal Title: 外科 72巻7号 Pages: 703-708
• [Journal Article] Phase I pharmacokinetic study of weekly intravenous and intraperitoneal paclitaxel combined with S-1 for advanced gastric cancer. (2009)
  • Author(s): Ishigami H, Kitayama J, Otani K, Kamei T, Soma D, Miyato H, Yamashita H, Hidemura A, Kaisaki S, Nagawa H
  • Journal Title: Oncology. 76(5) Pages: 311-4
  • Peer Reviewed
• [Journal Article] スキルス胃癌に対するPaclitaxel+ヒアルロン酸(NASHA)腹腔内投与の有用性について (2009)
  • Author(s): 北山丈二,山田純,名川弘一
  • Journal Title: 癌の臨床 55巻1号 Pages: 65-71
• [Journal Article] Intra-peritoneal administration of paclitaxel with non-animal stabilized hyaluronic acid as a vehicle--a new strategy against peritoneal dissemination of gastric cancer. (2008)
  • Author(s): Yamada J, Kitayama J, Tsuno NH, Yamashita H, Miyato H, Soma D, Otani K, Kamei T, Ishigami H, Hidemura A, Kaisaki S, Takahashi K, Nagawa H
  • Journal Title: Cancer Lett. 272(2) Pages: 307-15
  • Peer Reviewed
• [Presentation] Spatial Distribution of Intraperitoneally Administrated Paclitaxel Nanoparticles Solubilized with Poly (2-methacryloxyethyl phosphorylcholine-co n-butyl methacrylate) in Peritoneal Metastatic Nodules (2010)
  • Author(s): 北山丈二, ほか
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-24
• [Presentation] 腹膜播種に対するナノミセル化抗癌剤腹腔内投与の有用性 (2010)
  • Author(s): 北山丈二
  • Organizer: 第26回日本DDS学会
  • Place of Presentation: 大阪
  • Year and Date: 2010-06-18
• [Remarks] ホームページ等