2010 Fiscal Year Final Research Report
Identification of target genes for esophageal cancers through integrative analysis of genomic alterations and oncogene addiction
| Project/Area Number |
20591564
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
IMOTO Issei Tokyo Medical and Dental University, 大学院・ヘルスバイオサイエンス研究部, 教授 (30258610)
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| Co-Investigator(Kenkyū-buntansha) |
INAZAWA Johji 東京医科歯科大学, 難治疾患研究所, 教授 (30193551)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 食道癌 / アレイCGH / 遺伝子増幅 / DNAメチル化 / 癌遺伝子中毒 |
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| Research Abstract |
In order to identify target tumor-related genes for establishing molecular targeting therapy in patients with esophageal squamous-cell carcinoma, we integrated detailed information of genomic/epigenomic alterations in tumors, functional addiction of tumor cells to candidate target genes (oncogene addiction), and clinicopathological significance of altered expression status of those genes. Using this approach, we successfully identified a number of possible novel onocogene and tumor suppressor genes, which may be useful therapeutic as well as diagnostic targets for esophageal cancers.
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[Journal Article] Frequent silencing of protocadherin 17, a candidate tumour suppressor for esophageal squamous cell carcinoma.2010
Author(s)
Haruki S, Imoto I, Kozaki K, Matsui T, Kawachi H, Komatsu S, Muramatsu T, Shimada Y, Kawano T, Inazawa J.
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Journal Title
Carcinogenesis 31
Pages: 1027-1036
Peer Reviewed
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[Journal Article] Overexpression of SMYD2 relates to tumor cell proliferation and malignant outcome of esophageal squamous cell carcinoma.2009
Author(s)
Komatsu S, Imoto I, Tsuda H, Kozaki KI, Muramatsu T, Shimada Y, Aiko S, Yoshizumi Y, Ichikawa D, Otsuji E, Inazawa J.
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Journal Title
Carcinogenesis 30
Pages: 1139-1146
Peer Reviewed
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[Journal Article] Frequent inactivation of a putative tumor suppressor, angiopoietin-like protein 2, in ovarian cancer.2008
Author(s)
Kikuchi R, Tsuda H, Kozaki K, Kanai Y, Kasamatsu T, Sengoku K, Hirohashi S, Inazawa J, Imoto I.
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Journal Title
Cancer Res 68
Pages: 5067-5075
Peer Reviewed
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[Remarks] ホームページ
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