2010 Fiscal Year Final Research Report
Integrated analysis of microRNA expression and epigenetics in esophageal cancer
| Project/Area Number |
20591569
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kyoto University |
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Principal Investigator |
SATO Fumikai Kyoto University, 薬学研究科, 准教授 (20467426)
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| Co-Investigator(Kenkyū-buntansha) |
TSUCHIYA Soken 京都大学, 薬学研究科, 助教 (80423002)
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| Co-Investigator(Renkei-kenkyūsha) |
SHIMADA Yutaka 富山大学, 医学部, 准教授 (30216072)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 食道癌 / エピジェネティクス / マイクロRNA |
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| Research Abstract |
In this project, an integrated analysis of epigenetic and microRNA expression in esophageal cancer cells was performed. We obtained genomewide information of DNA methylation, by high-throughput sequencer, and we showed that miR-106b cluster, miR-141, miR-210, miR-593* target p21/Bim, YAP1, EGFRL1, and PLK1, respectively, to regulate cell growth, cell cycle, chemo-resistance of esophageal cancer. This finding provided deep biological insights into esophageal cancer research field.
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[Journal Article] Polo-like kinase 1 regulates cell proliferation and is targeted by miR-593* in esophageal cancer.2010
Author(s)
Ito T, Sato F, Kan T, Cheng Y, David S, Agarwal R, Paun BC, Jin Z, Olaru AV, Hamilton JP, Selaru FM, Yang J, Matsumura N, Shimizu K, Abraham JM, Shimada Y, Mori Y, Meltzer SJ.
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Journal Title
Int J Cancer.(* : equally contributed)
Peer Reviewed
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[Journal Article] A multicenter, double-blinded validation study of methylation biomarkers for progression prediction in Barrett's esophagus.2009
Author(s)
Jin Z, Cheng Y, Gu W, Zheng Y, Sato F, Mori Y, Olaru AV, Paun BC, Yang J, Kan T, Ito T, Hamilton JP, Selaru FM, Agarwal R, David S, Abraham JM, Wolfsen HC, Wallace MB, Shaheen NJ, Washington K, Wang J, Canto MI, Bhattacharyya A, Nelson MA, Wagner PD, Romero Y, Wang KK, Feng Z, Sampliner RE, Meltzer SJ.
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Journal Title
Cancer Res. 69
Pages: 4112-5
Peer Reviewed
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[Journal Article] The miR-106b-25 polycistron, activated by genomic amplification, functions as an oncogene by suppressing p21 and Bim.2009
Author(s)
Kan T, Sato F, Ito T, Matsumura N, David S, Cheng Y, Agarwal R, Paun BC, Jin Z, Olaru AV, Selaru FM, Hamilton JP, Yang J, Abraham JM, Mori Y, Meltzer SJ.
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Journal Title
Gastroenterology. 136
Pages: 1689-700
Peer Reviewed
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[Journal Article] Pituitary tumor-transforming 1 increases cell motility and promotes lymph node metastasis in esophageal squamous cell carcinoma.2008
Author(s)
Ito T, Shimada Y, Kan T, David S, Cheng Y, Mori Y, Agarwal R, Paun B, Jin Z, Olaru A, Hamilton JP, Yang J, Abraham JM, Meltzer SJ, Sato F
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Journal Title
Cancer Res. 68
Pages: 3214-24
Peer Reviewed
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[Journal Article] Promoter hypermethylation of CDH13 is a common, early event in human esophageal adenocarcinogenesis and correlates with clinical risk factors.2008
Author(s)
Jin Z, Cheng Y, Olaru A, Kan T, Yang J, Paun B, Ito T, Hamilton JP, David S, Agarwal R, Selaru FM, Sato F, Abraham JM, Beer DG, Mori Y, Shimada Y, Meltzer SJ.
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Journal Title
Int J Cancer. 123
Pages: 2331-6
Peer Reviewed
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[Journal Article] Hypermethylation of the AKAP12 promoter is a biomarker of Barrett's-associated esophageal neoplastic progression.2008
Author(s)
Jin Z, Hamilton JP, Yang J, Mori Y, Olaru A, Sato F, Ito T, Kan T, Cheng Y, Paun B, David S, Beer DG, Agarwal R, Abraham JM, Meltzer SJ.
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Journal Title
Cancer Epidemiol Biomarkers Prev. 17
Pages: 111-7
Peer Reviewed
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[Journal Article] Hypermethylation of the somatostatin promoter is a common, early event in human esophageal carcinogenesis.2008
Author(s)
Jin Z, Mori Y, Hamilton JP, Olaru A, Sato F, Yang J, Ito T, Kan T, Agarwal R, Meltzer SJ.
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Journal Title
Peer Reviewed
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[Journal Article] Three-tiered risk stratification model to predict progression in Barrett's esophagus using epigenetic and clinical features.2008
Author(s)
Sato F, Jin Z, Schulmann K, Wang J, Greenwald BD, Ito T, Kan T, Hamilton JP, Yang J, Paun B, David S, Olaru A, Cheng Y, Mori Y, Abraham JM, Yfantis HG, Wu TT, Fredericksen MB, Wang KK, Canto M, Romero Y, Feng Z, Meltzer SJ.
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Journal Title
Peer Reviewed
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[Presentation] #M1600 Upregulation of the Mir-25-93-106b Cluster in Barrett's-Associated Neoplastic Progression.(Gastroenterology)2008
Author(s)
Kwisa Kang, Fumiaki Sato, Tetsuo Ito, Stefan David, Yulan Cheng, Yuriko Mori, Rachana Agarwal, Bogdan C. Paun, Zhe Jin, Alexandru Olaru, Florin Selaru, James P. Hamilton, Jian Yang, John M. Abraham, Stephen J. Meltzer.
Organizer
DDW 2008(134(4))(A379-80)
Place of Presentation
San Diego.
Year and Date
20080517-20080522
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[Presentation] #M2005 Down-Regulation of PTTG1 By siRNA Suppresses Tumorigenesis and Lymph Node Metastasis of Esophageal Squamous Cell Carcinoma In Vivo.(Gastroenterology)2008
Author(s)
Tetsuo Ito, Fumiaki Sato, Kwisa Kang, Stefan David, Yulan Cheng, Yuriko Mori, Rachana Agarwal, Bogdan C. Paun, Zhe Jin, Alexandru Olaru, James P. Hamilton, Florin M. Selaru, Jian Yang, Yutaka Shimada, John M. Abraham, Stephen J. Meltzer.
Organizer
DDW 2008(134(4))(A-449)
Place of Presentation
San Diego.
Year and Date
20080517-20080522
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[Presentation] #5012 The mir-106b cluster in Barrett's esophagus and esophageal adenocarcinoma.2008
Author(s)
Kan T, Sato F, Ito T, Jin Z, Olaru AV, Paun BC, David S, Selaru FM, Hamilton JP, Cheng Y, Yang J, Mori Y, Abraham JM, Meltzer SJ.
Organizer
AACR 2008
Place of Presentation
San Diego.
Year and Date
2008-04-16
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[Presentation] #3456 Down-regulation of Polo-like Kinase 1 by siRNA drastically suppresses proliferation of esophageal cancer cells.2008
Author(s)
Ito T, Sato F, Kan T, David S, Cheng Y, Mori Y, Agarwal R, Paun B, Jin Z, Olaru AV, Hamilton JP, Selaru FM, Yang J, Shimada Y, Abraham JM, Meltzer SJ.
Organizer
AACR 2008
Place of Presentation
San Diego.
Year and Date
2008-04-15
